Scientist Bioscience
Listed on 2026-10-12
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Research/Development
Research Scientist, Biotech Research, Biomedical Science, Drug Discovery
Job Title: Research Scientist - Chemical Biology & Proteomics
Location: Cambridge, MA (100% Onsite)
Pay Rate: $50/hour
Duration: 12 Months
Schedule: Monday-Friday, 8:00 AM-4:00 PM
Join the Chemical Biology and Proteomics team to apply mass spectrometry-based proteomics in drug discovery and mechanism-of-action studies. Design and execute proteomic assays, perform affinity enrichment and proximity biotinylation workflows, and analyze experimental data to investigate protein interactions and disease biology. Perform mammalian cell culture, protein conjugation, purification, and UV-Vis spectroscopy characterization. Conduct target validation using cell-based assays and maintain accurate electronic laboratory records.
EducationPh.D. in Proteomics, Chemical Biology, Biological Sciences, Biochemistry, or a related discipline, with at least 2 years of hands-on proteomics experience, including graduate or postdoctoral research; OR
Master's degree with at least 1 year of industry proteomics experience and 3-5 years of hands-on laboratory experience.
Hands-on proteomics experience, including proteomic sample preparation and mass spectrometry-based analysis.
Experience with mammalian cell culture.
Experience with affinity enrichment workflows and protein characterization.
Experience using cell-based and proteomic assays to investigate small-molecule mechanisms of action.
Data analysis and interpretation using established bioinformatics pipelines.
Ability to independently design and execute experiments and interpret scientific results.
Experience developing or applying proximity ligation assays (PLA) or other protein-protein interaction assays.
Experience with proximity biotinylation and data-independent acquisition (DIA) mass spectrometry.
Hands-on experience with LC-MS/MS platforms and semi-automated instrumentation.
Familiarity with Spectronaut, Proteome Discoverer, Max Quant, Skyline, or Xcalibur.
Experience with confocal microscopy and protein conjugation techniques.
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