Senior Scientist, Bioconjugation & Targeted Nanomedicine

We are seeking a highly motivated and innovative Senior Scientist to join BMS’s Non-Viral Delivery team and advance next-generation targeted nanomedicine, engineering the molecular interfaces that make selective, cell type-specific delivery possible. Embedded within a highly collaborative, multidisciplinary team, you will drive the design, development, and optimization of bioconjugation strategies and targeting ligand architectures that expand what targeted nanoparticles can achieve, unlocking new therapeutic possibilities across challenging cell types and tissues.

Working at the interface of chemistry, chemical biology, and nanomedicine, you will help establish the molecular and chemical foundations that translate conjugate design into functional, next-generation delivery systems. The ideal candidate brings deep expertise in bioconjugation chemistry, a creative and rigorous approach to molecular design and problem-solving, and a collaborative mindset for advancing complex delivery technologies.

• Design and develop bioconjugation strategies for targeted nanoparticles across a variety of targeting ligand formats, including antibodies, fragments, and peptides, and nanoparticle surface components.
• Develop and optimize conjugation chemistries and linker strategies across ligand formats to achieve controlled, well-defined conjugates.
• Contribute to targeting ligand engineering, including format selection, conjugation site design, and sequence-level modifications that enable controlled conjugation and functional ligand presentation.
• Develop and apply analytical workflows to characterize bioconjugates to support lead selection and targeted nanoparticle evaluation.
• Develop strategies for integrating targeting ligands into nanoparticle systems and characterize how conjugate design and ligand presentation influence nanoparticle properties and functional delivery.
• Collaborate cross-functionally across protein engineering, formulation and delivery sciences, analytical sciences, immunology, and in vivo pharmacology to translate molecular design into improved targeted nanoparticle architectures and delivery performance.
• Effectively communicate scientific findings and actionable recommendations to multidisciplinary teams and leadership to influence delivery strategy and program decisions.
• Provide scientific mentorship to junior scientists, and contribute to a collaborative, growth-oriented team culture.

• Bachelor’s Degree
  • 7+ years of academic and / or industry experience
• Master’s Degree
  • 5+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences
  • 2+ of academic and / or industry experience

• PhD in Organic Chemistry, Bioengineering, Protein Engineering, Pharmaceutical Sciences, or a related discipline with 2+ years of relevant industry experience; or MS with 5+ years; or BS with 7+ years of relevant experience.
• Strong hands‑on expertise in bioconjugation, linker chemistry, and analytical characterization.
• Demonstrated experience with bioconjugation across a variety of biomolecular formats, including proteins, antibodies, antibody fragments, and peptides.
• Experience with nanoparticle‑based or other complex delivery systems, is desirable.
• Experience with therapeutic conjugate platforms and linker design across modalities, including ADCs, peptide conjugates, or oligonucleotide conjugates, is desirable.
• Hands‑on experience with analytical and purification methods for bioconjugate characterization, including LC‑MS, HPLC/UPLC, SEC, IEX, HIC, SDS‑PAGE, UV/Vis, and AKTA‑based chromatography.
• Demonstrated ability to work effectively in multidisciplinary teams and thrive in a highly…