Principal Scientist, Translational Science Program Lead, Immunology

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Translational Discovery & Development Biomarkers

Job Category:
Scientific/Technology

All Job Posting Locations:
Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

We are searching for the best talent for a Principal Scientist, Translational Science Program Lead – Immunology, for Immunology programs spanning discovery through clinical development. This role is located onsite in either Cambridge, MA or Spring House, PA. The TSPL will be the scientific and strategic owner of the end‑to‑end translational strategy for assigned assets, translating therapeutic mechanism and human disease biology into decision‑linked evidence plans that guide portfolio entry, dose and regimen selection, proof of biology, patient stratification, clinical development, and regulatory strategy.

The successful candidate will lead through scientific credibility and influence in a highly matrixed environment. They will anticipate upcoming program decisions, integrate expertise across functions, and mobilize teams toward clear recommendations and execution.

• Own the translational strategy:
  Develop and maintain integrated, stage‑appropriate translational plans that connect disease biology, therapeutic mechanism, pharmacology, biomarkers, clinical endpoints, and key program decisions.
• Anticipate evidence needs:
  Work one or more inflection points ahead to define critical questions, evidence requirements, decision criteria, timelines, dependencies, risks, and mitigation options.
• Lead precision medicine strategy:
  Develop testable hypotheses for disease segmentation, patient stratification or selection, response and non‑response, and clinically meaningful biomarker endpoints; integrate these hypotheses into target product profiles, study designs, and stage‑gate decisions.
• Translate science into clinical plans:
  Define biomarker strategies addressing target engagement, pharmacodynamic activity, proof of biology, dose and regimen selection, disease heterogeneity, efficacy, safety, and differentiation.
• Lead in the matrix:
  Represent Translational Science on discovery and clinical development teams and align Discovery, Clinical Development,…