Principal Associate Scientist, Biology

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable.

The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigationalmedicine,zolucatetide, is the first and only direct inhibitor of theβ-catenin:

TCFinteraction,a central node in theWnt/β-catenin pathway that haseluded drug developers for decades.

Zolucatetideis being evaluated in the clinic across multiple

Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) anda rangeofothersolid tumor indications. Beyondzolucatetide,Parabilisis advancing additional

Helicon-based programs focused on other challenging targets where we believeourmedicines could have life-altering impact. For more information, visit (Use the "Apply for this Job" box below). follow us on Linked In.

We are seeking a highly motivated, hands-on Principal Associate Scientist to join our Biology team and support the advancement of pre-clinical oncology programs. This scientist will be a key bench-facing member of the program, designing and executing the cellular and molecular experiments to understand how Helicon candidates engage and interfere with the target; how target interference alters cancer-cell biology, and which pharmacodynamic and response biomarkers may help translate the mechanism toward development.

The successful candidate will generate rigorous, decision-enabling data and provide scientifically grounded recommendations to help define translational and clinical opportunities for addressing significant unmet medical needs.

Reporting to the program biology lead, the ideal candidate combines excellent experimental skills with strong mechanistic reasoning. This individual will work independently on problems of diverse scope, develop and qualify new assays, adapt published approaches to novel scientific questions, and generate high-impact biology data in a highly collaborative, fast-paced biotechnology environment.

• Independently design, optimize, execute, and troubleshoot cell-based assays to characterize and assess lead Helicons, including target engagement, potency, selectivity, mechanism of action, and differentiation opportunities.
• Develop and apply cellular and molecular assays, including CETSA, AlphaLISA, HTRF, NanoBRET, cell proliferation, qPCR, ELISA/MSD, Co-IP, flow cytometry, and western blot across 2D and 3D cell models.
• Develop, optimize, and qualify new assay systems and disease-relevant models—including cancer cell lines, primary cells, and 3D organoid cultures—to address questions that existing platforms cannot answer.
• Investigate the biological contexts associated with sensitivity and resistance to lead Helicons and develop testable hypotheses for pharmacodynamic and response biomarkers.
• Work with Translational Biology, DMPK and in vivo Pharmacology colleagues to select informative models and translate cellular findings into tissue PK/PD and biomarker studies where appropriate.
• Collaborate closely with other functions within the program to generate decision-enabling biology data supporting lead optimization, development-candidate nomination and IND-enabling activities.
• Present experimental results, interpretations, and recommendations clearly to project teams, the broader Biology and company organizations.
• Maintain complete, timely and traceable experimental records and uphold high standards for data integrity, reproducibility and scientific…