Apriori Bio: Protein Science Co-Op

This position is open exclusively to current Northeastern University Co-Op students.

Work Period: January 2027 to June 2027. This is a full-time, 40 hours per week position with 5 days in office.

Join Our Innovative Team at Apriori Bio!

Are you ready to be part of a pioneering biotech company on the frontline of developing solutions against rapidly evolving viruses like influenza and SARS-CoV-2? At Apriori Bio, we’re creating a safer world through resilient vaccines and advanced antibody therapeutics using our cutting-edge Octavia platform.

About Flagship Pioneering

Apriori Bio was founded by Flagship Pioneering’s venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies

Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, andhas been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Learn more about Flagship at

Flagship Pioneering Co-Op Program

Welcome to the Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You’ll join fellow peers across our ecosystem of companies and learn firsthand how we build first-in-category companies. You’ll have access to enrichment sessions , a dedicated professional development track , and a mentorthat help guide you toward your next step. By the end, you will carry on a meaningful project outcome, a genuine network , anda front-row view of how Flagship pioneers new ventures that change the world.

The Role

As a member of our protein science team, you’ll help turn computationally designed vaccine immunogens into well-characterized proteins. Our team produces antigens in multiple formats for antigen validation and in-vivo studies, and develops the assays used to characterize and functionally validate them.

We’re Looking For:

Individuals with a background in biochemistry, molecular biology, or bioengineering and a desire to master protein expression, purification, and characterization.

What You’ll Do:

• Express recombinant vaccine antigens and antibodies in mammalian expression systems, including small-scale transient transfection and scale-up.
• Purify proteins using affinity and size-exclusion chromatography on ÄKTA systems.
• Characterize protein quality and stability using SDS-PAGE, analytical SEC, and thermal stability methods such as DSF.
• Contribute to the development and execution of binding and functional assays, including ELISA and bio-layer interferometry (BLI), to assess antigenicity against panels of monoclonal antibodies.
• Document experiments in our electronic lab notebook (Benchling) and present results at team meetings.

Qualifications:

• Pursuing a BS or MS in Biochemistry, Bioengineering, Chemical Engineering, Molecular Biology, or a related field
• Hands-on laboratory experience (coursework or research), such as SDS-PAGE, solution preparation, and accurate pipetting
• Experience with mammalian cell culture and aseptic technique
• Preferred: exposure to protein…