Vice President, Therapeutics Immunology

Vice President, Therapeutics Immunology### Vice President, Therapeutics Immunology Apply:
Cambridge, Massachusetts:
Research:
Full time:
Posted Today:
R20061
*
* The Role:

** Moderna is seeking an exceptional scientific leader to lead its Therapeutics Immunology organization as Vice President, Therapeutics Immunology. Reporting to the Chief Scientific Officer, Therapeutics, this leader will be responsible for developing and driving the scientific strategy for the immunology mRNA portfolio. This leader will build a differentiated T cell receptor capability and advance immunology programs from discovery through preclinical development, while shaping broader portfolio and technology decisions.

The role will connect deep immunology expertise with Moderna's mRNA, delivery, protein engineering, and computational platforms to create medicines that address the underlying biology of immune-mediated disease.

The successful candidate will be a recognized T cell immunologist and experienced drug-discovery leader with a demonstrated ability to build high-performing multidisciplinary teams and establish new scientific capabilities. They will lead teams spanning T cell biology, immune repertoire and TCR discovery, functional immunology, protein and antibody engineering, and preclinical research. As a senior member of the Research organization, they will work closely with Bioinformatics / AI teams, Platform Science, Nonclinical Development, Clinical Development, Translational Medicine, CMC Development, Regulatory, and R&D Strategy teams to ideate product concepts and modalities, define therapeutic hypotheses, select candidates, and guide programs toward the clinic.
** Here’s

What You’ll Do:

*** Set and execute the scientific strategy for the mRNA therapeutics immunology pipeline, establishing clear priorities across autoimmune disease, TCR-based medicines, and immune-modulating therapeutics.
* Oversee internal TCR capabilities including TCR deconvolution and an end-to-end TCR discovery and engineering engine to generate therapeutic TCRs at scale.
* Lead the autoimmune research portfolio from concept ideation to target and disease hypothesis through lead generation, candidate selection, pharmacology, translational strategy, and preclinical development.
* Establish rigorous decision criteria for efficacy, selectivity, cross-reactivity, develop ability, manufacturability, and translational relevance across immune-mediated mRNA modalities – including but not limited to T cell engagers and in vivo cell therapy.
* Translate insights from patient samples, single-cell and immune-repertoire data, human genetics, functional genomics, and disease models into therapeutic concepts.
* Partner with mRNA science, lipid nanoparticle delivery, protein engineering, structural biology, computational biology, and AI teams to design medicines that exploit Moderna's technology platform and are differentiated from the external landscape.
* Serve as a key scientific partner to Clinical Development. Shape mechanism-based development plans, biomarker and patient-selection strategies, clinical pharmacology hypotheses, proof-of-mechanism studies, and interpretation of emerging clinical data.
* Shape Moderna’s R&D strategy by representing therapeutics immunology and autoimmune programs in senior cross-functional forums and integrating Therapeutics Immunology priorities with enterprise portfolio decisions. Regularly engage with senior Research and Development leaders and Executive Committee members. Present clear recommendations, identify scientific and execution risks early, and make evidence-based portfolio and resource decisions.
* Lead Therapeutics Immunology organization through senior scientific and functional leaders, establishing clear…