Associate Scientist, HTS & NGS

Location:
Cambridge, MA – Onsite

Position Summary:

biotech client is seeking a highly motivated contract Associate Scientist to join our HTS-NGS operations team and work with an enthusiastic team of highly skilled scientists. The ideal candidate for this lab-based position is committed to delivering high quality results in a timely manner. This is an exciting opportunity to be part of a collaborative team and contribute to the development of next-generation RNA editing technology and therapeutics in a fast-paced biotech company.

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• Independently design and execute high-throughput cell-based assays to support oligonucleotide platform and portfolio projects
• Perform amplicon-seq library preparation and quality control, operate and maintain NGS platforms and associated laboratory equipment
• ? Troubleshoot HTS assays, library preparation, and sequencing workflows as needed
• Analyze and present HTS‑NGS data based on results in a team setting; collaborate with cross‑functional teams to support lead discovery
• Support NGS scientists in operational tasks, including inventory management, assay development, and operations improvement
• Accurately document project and sample information, protocols, and experimental details through an Electronic Lab Notebook (ELN)

• MS with 3+ years or BS with 5+ years of experience in molecular biology, cell biology, or related field
• 1+ years of hands‑on experience with high‑throughput assays and automated workflows
• Experience with cell culture techniques, including plating and transfection in 96/384‑well formats
• Experience with NGS assays: amplicon‑seq and RNA‑seq, including primer design, library preparation, quantification, and data quality control
• Demonstrated expertise in molecular biology techniques: RNA/DNA isolation, transfection, PCR/qPCR, gel electrophoresis
• Familiarity with liquid handling systems (e.g., Viaflo
  96/384, HiRes/Certus Flex, Tempest) is highly preferred
• Hands‑on experience with next‑generation sequencing platforms and equipment including Illumina (MiSeq i100), Qubit, Tape Station, and Fragment Analyzer is highly preferred
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  Experience with LIMS systems (Benchling) and project management tools (Jira/Confluence)??
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  Strong troubleshooting skills and ability to suggest and implement new solutions independently
• Excellent written and verbal communication skills with attention to detail
• Ability to thrive in a fast‑paced and evolving environment