Senior Scientist , Computational Biology

Cambridge, MA

Join our team and drive the future of programmableeRNA eRNA In VivoCAR-T therapies- where artificial intelligence, targeted delivery systems and next-generation immunotherapy converge to redefine what'spossible for patients.

As a key member of the Sail Biomedicines Computational Biology team, the Senior Scientist I will operate at the interface of platform and program, applying data-driven approaches tochampionbroad platform effortsandhands-on analysis of preclinical datasets to transform the treatment landscape for autoimmune diseases,and beyond.

Theideal candidate brings a strong foundation in computational biology and a record of independently developing, implementing, and critically evaluating computational methods for biological research. They should be comfortable reasoning through methodological assumptions, limitations, and biological implications of an analysis, from raw measurements through interpretation.

The role will directly support In VivoCAR-T immunology programs and platform development,with opportunities to contribute to building capabilities spanning molecular and systems modeling, computational protein design, and AI-based therapeutic engineering.

• Lead analysis ofpreclinical research datasets,including immunophenotyping, functional assays, and multi-omics datato support therapeutic development
• Develop, adapt, and benchmark computational and statistical methods to address biological questions where standard workflows are insufficient
• Integrate and interpret data across studies leveraging internal and external resources to contextualize findings, evaluate consistency, and strengthen understanding of our therapeutics
• Partner with experimental scientists to shape experimental design, identify limitations, interpret results, and prioritize follow-up studies.
• Build and maintain reproducible analysis workflows, with clear documentation and version control(Git) with consistent data annotation and metadata practices.
• Communicate findings, uncertainty, and implications with collaborators through effective visualizations, presentations, and written summaries

Required:

• Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Biophysics, or a related quantitative discipline.
• 3+ years of hands-on computational biology research in biotech, pharma, or academia.
• A record of independently leading substantial computational biology projects, including developing, adapting, and benchmarking analytical methods. Evidence may include methods development, reusable scientific software, publications, or documented contributions to therapeutic research.
• Deep expertise in at least one relevant area, such transcriptomics, multi-omics analysis, or quantitative analysis of preclinical studies, spanning data generation, quality control, methodological choices, and biological interpretation.
• Strong grounding in statistical modeling, with demonstrated ability to address confounding, batch effects, biological versus technical variation, and experimental-design limitations, and to assess uncertainty and sensitivity to analytical choices.
• Strong programming skills in Python and/or R, with experience independently developing and maintaining reproducible, well-documented scientific analysis code and workflows.
• Demonstrated ability to collaborate effectively with experimental scientists, take ownership of scientific questions, be a proactive force driving improvement, and being comfortable developing to contribute beyond your core area of expertise.

Preferred:

• Experience in CAR biology, immunology, cell therapy, or RNA therapeutics.
• Experience integrating heterogeneousdatasetsacross studies or conducting meta-analysis
• Experience with workflow orchestration tools to cloud-based or collaborative data environments
• Track recordof impactful scientific contributions (publications or program support)
• Computational protein design and / or structural biology experience a plus

Sail Biomedicines is building a new class offully programmable medicines by integrating circular RNA (eRNA), targeted nanoparticle delivery, and advanced computational approaches. Our platform enables the systematic design and optimization of therapies, unlocking new possibilities across immunology and beyond.

Salary Range: $130,000 - $170,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual…