ProFound Therapeutics: AI​/ML Engineering - SAGE Platform Co-Op

This position is open exclusively to current Northeastern University Co-Op students.

Location:

Watertown, MA
Work Period: January 2027 to June 2027. This is a full - time, 40 hours per week position with hybrid schedule.

Pro Found™ Therapeutics is a biotechnology company discovering novel proteins across the expanded human proteome to unlock first-in-class medicines and transformative drug targets. The company’s proprietary

Pro Foundry™ Platform integrates state-of-the-art protein detection, validation, and computational technologies to systematically identify and characterize previously inaccessible proteins and validate their therapeutic potential. This approach has generated a rapidly expanding portfolio of novel targets and drug discovery programs advancing toward the clinic, enabled by strategic collaborations with leading pharmaceutical partners. Together, these efforts support the development of breakthrough treatments across a broad range of disease areas.

The company is now poised to define the disease-relevant function of these proteins at scale using advanced proteomics technologies, high throughput experimental biology, and causal agentic AI, enabling rapid identification and characterization of the most promising protein drugs and drug targets.

Founded by Flagship Pioneering,Pro Found works with pharmaceutical partners including Novartis, Pfizer and GSK, and with the Gates Foundation, which has committed up to $35 million to aProFoundprogram focused on preeclampsia.

Pro Found Therapeutics was founded by Flagship Pioneering’s venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the company’s Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Learn more about Flagship at

Welcome to Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You’ll join fellow peers across our ecosystem of companies and learning firsthand how we build first-in-category companies. You’ll have access to enrichment sessions , a dedicated professional development track , and a mentor that help guide you toward your next step. By the end, you will carry on a meaningful project outcome , a genuine network , and a front-row view of how Flagship pioneer new ventures that change the world.

Pro Found’s AI/ML team builds SAGE, an internal multi-agent LLM platform that helps our scientists reason over knowledge graphs, biological databases and the scientific literature. SAGE is a central part of how Pro Found applies agentic AI to understand novel proteins and accelerate drug discovery.

As an AI/ML Engineering Co-Op, you will help extend what SAGE can do and make sure it performs reliably. You will own real features from design through deployment, working closely with our ML engineers and with the scientists who use SAGE every day. The Co-Op is designed to complement your…