Experienced Scientist, Proteomics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Discovery & Pre-Clinical/Clinical Development

Biological Research

Scientific/Technology

Cambridge, Massachusetts, United States of America

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

We are searching for the best talent for an Experienced Scientist, Proteomics to be located in Cambridge, MA.

Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis. Be part of a motivated team deploying cutting-edge mass spectrometry technologies to tackle challenges in end-to-end drug discovery and development.

Work across a leading multiomics organization to provide coordinated insights across a variety of 'omics layers. This is a hands-on laboratory role, fit for a scientist who thrives at the bench and wants to grow in experimental design and scientific communication by working closely with senior scientists. With your help, we will drive development of medicines for our patients!

• Joining a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities.
• Planning and performing wet lab proteomic activities supporting evaluation of therapeutic candidates.
• Generating samples for proteomics analysis from multiple sources (immortalized cell lines, FFPE, fresh-frozen tissue, plasma/serum, etc.).
• Maintaining multiple cell lines in both flasks and plates.
• Preparing assay plates and performing chemical treatments and perturbations.
• Applying high-efficiency proteomics sample preparation methodologies across many experiment types (global proteomic profiling, immunoprecipitation, affinity, PTM analysis).
• Operating and maintaining LC-MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, Ulti Mate 3000), including daily/weekly maintenance, calibration, and troubleshooting.
• Deploying automation-supported workflows for high-throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx.
• Ensuring QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation.
• Collaborating with colleagues within the proteomics group to drive proteomics experiments across the drug discovery portfolio.
• Demonstrating creativity and applying novel approaches to solving scientific problems.
• Proposing novel and practical ideas aligned with scientific strategies and demands.

A Master's degree with 1+ years, or a Bachelor's degree with 3+ years, of proven…