Senior Scientist, ADC Chemistry

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Cambridge, US | full time | Job

BioNTech is developing novel Antibody-Drug Conjugates (ADCs), protein degraders and other targeted therapeutics for the targeted treatment of cancer with the goal of maximizing efficacy and minimizing toxic effects to patients. To achieve this goal ADCs and/or degraders will be prepared, evaluated in a battery of in vitro and in vivo assays, then based on results, improved therapeutics will be developed.

As a Chemistry Senior Scientist in the ADC Innovation Unit, you will help design and synthesize the payloads, linkers and linker‑payloads required to prepare ADCs. You may also be involved in the conjugation step, attaching linker‑payloads to antibodies. You will work closely with team members who have diverse backgrounds in Biology, Pharmacology and other disciplines. You will also prepare presentations for the team, and possibly for upper management, that will include progress updates and proposals for linker‑payload improvements.

• Work with a team designing and producing protein degraders, ADCs and other targeted therapeutics
• Design, synthesize, and purify small molecules, peptides, potent payloads, and potentially conjugate them to proteins.
• Work in a safe manner, using appropriate containment for potent compounds.
• Use NMR and HPLC/UPLC techniques to prove the identity and purity of prepared compounds
• Prepare presentations and work cross‑functionally within the organization in various areas including formulation, drug delivery, pharmacokinetics, and pharmacodynamics
• Liaise with BioNTech partners, CROs and CDMOs

• Ph.D. in synthetic organic chemistry, with 3 plus years of industry experience developing PROTACs, molecular glues, or other types of protein degraders
• Hands‑on experience preparing complex organic molecules and using HPLC, LC‑MS and NMR for purification/analysis
• Proven track record of creative thinking and consistent delivery as demonstrated by publications and presentations
• Excellent interpersonal, networking, and communication skills
• Must be able to work on site in our synthetic laboratory

• Experience with analytical methods used in degrader development
• Experience in molecular modeling
• Experience in ADC chemistry

Expected Pay Range: $113,600 to $181,600/year + benefits, annual bonus & equity (bonus and equity is variable and dependent on company and individual performance).
* Compensation for the role will depend on several factors, including responsibilities of the job, education, experience, knowledge, skills, and abilities.

BioNTech US is committed to employee wellbeing and offers best‑in‑class benefits & HR programs to support an inclusive & diverse workforce. Salaried/Position‑Targeted Hourly Employees working 30+ hours per week are eligible for our comprehensive benefits package. Benefits include but are not limited to:

• Medical, Dental and Vision Insurance
• Life, AD&D, Critical Illness Insurance
• Pre‑tax HSA & FSA, DCRA Spending Accounts
• Employee Assistance & Concierge Program (EAP) available 24/7
• Parental and Childbirth Leave & Family Planning Assistance
• Sitter stream:
  Virtual Tutoring & Childcare Membership
• Paid Time Off:
  Vacation, Sick, Bereavement, Holidays (including Floating) & Year‑End U.S. Shutdown.
• 401(K) Plan with Company Match
• Tuition Reimbursement & Student Loan Assistance Programs
• Professional Development Programs
• Commuting Allowance and subsidized parking
• Discounted Home, Auto & Pet Insurance

…and more! More details to be shared.

Home to dozens of research institutions, biopharmaceutical companies, life science incubators, venture capital firms, and over 30 million square feet of laboratory space, Cambridge, Massachusetts has earned a reputation as the #1 life science cluster in the world. As part of the Greater Boston area, the city is often referred to as the "biotech supercluster" due to its high concentration of life sciences firms.

This unique ecosystem is the result of a model partnership between academia and industry, fostering collaboration and innovation and driving the development of new therapies, medical devices, and…