Scientist II, ASO Process Development and Manufacturing

** About This Role
** We are looking for a highly motivated and creative Scientist II to join our Oligonucleotide Chemical Development team.

This role offers an exciting opportunity to contribute to the development of robust processes for synthesizing oligonucleotides. As part of this team, you will gain hands-on experience in designing and developing manufacturing processes for clinical and commercial therapeutics. You will play a pivotal role in optimizing synthesis processes, focusing on enhancing process robustness, productivity, and impurity control. Your work will have a significant impact on advancing our therapeutic capabilities, fitting into the broader mission of delivering innovative solutions to improve patient lives.
** What You’ll Do
*** Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize and/or characterize the synthesis processes of oligonucleotides with an emphasis on improvement in process robustness and productivity and control of impurities.
* Perform pilot-scale syntheses to produce oligonucleotide compounds for purification process development and/or preclinical studies.
* Record the experimental procedures and data accurately.
* Communicate research results effectively by writing research reports and presenting data in team meetings.
* Engage in the CMC activities including authoring CMC section of INDs.
* Manage the Contract Research Organization (CRO)
* Initiate innovative research projects to improve synthesis processes.
** Who You Are
** You have a passion for exploring novel scientific concepts and are eager to contribute to developing cutting-edge technologies in oligonucleotide synthesis. Your vision and dedication drive you to push the boundaries of Biogen’s scientific endeavors, ultimately impacting patient lives. You thrive in a collaborative environment and are committed to advancing innovative solutions.
** Required Skills
*** Specialization in synthetic organic chemistry with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.
* Ph.D. with 0-3 years of relevant postdoc experience.
* M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.
* BS with 6+ years of relevant experience in pharmaceutical or biotech settings
* Ability to perform synthetic process research and development of drug candidates including conjugates and starting materials beyond platform oligonucleotides by using information from literature, conferences, seminars etc.
* Knowledge in patent applications and manuscripts for publications.
* Ability to work independently and collaboratively within a team environment.
* Effective communication skills in both written and oral forms.
** Preferred Skills
*** Experience in nucleoside chemistry or oligonucleotide synthesis
* Experience in API synthesis process development

Job Level: Management
** Additional Information
** The base compensation range for this role is: $-$Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance. In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families
* physical, financial, emotional,
* and
* social well-being*; including, but not limited to:
* Medical, Dental, Vision, & Life insurances
* Fitness & Wellness programs including a fitness reimbursement
* Short- and Long-Term Disability insurance
* A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
* Up to 12 company paid holidays + 3 paid days off for Personal Significance
* 80 hours of sick time per calendar year
* Paid Maternity and Parental Leave benefit
* 401(k) program participation with company matched contributions
* Employee stock…