Biomolecular NMR Spectroscopist

ROLE OVERVIEW
We are currently looking for a Biomolecular NMR Spectroscopist to join a leading pharmaceutical company based in the Cambridge, UK area. As the Biomolecular NMR Spectroscopist, you will be responsible for providing NMR support for a proprietary fragment-based drug discovery (FBDD) platform, focusing on oncology and CNS targets.

KEY

DUTIES AND RESPONSIBILITIES:

Your duties as the Biomolecular NMR Spectroscopist will be varied; however, the key duties and responsibilities are as follows:
1. Develop ligand- and protein-observed NMR assays.
2. Perform NMR-based fragment screening and validate and characterise hits.
3. Use NMR to generate high-quality data on protein–ligand interactions, including affinity, kinetics, and mechanism of action.
4. Express and purify isotopically labelled protein samples.

ROLE REQUIREMENTS:

To be successful in your application to this exciting role as the Biomolecular NMR Spectroscopist, we are looking to identify the following on your profile and past history:
1. Relevant degree in a scientific discipline.
2. Proven industry experience in protein NMR spectroscopy.
3. A working knowledge and practical experience with Bruker NMR spectrometers.
Key Words:
Biomolecular NMR Spectroscopist / protein NMR / fragment-based drug discovery / FBDD / oncology / CNS targets / NMR assays / protein-ligand interactions / Bruker NMR / isotopically labelled proteins / drug discovery