Early Development Program Lead

At Insmed every moment and every patient counts and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases youll be part of a community that prioritizes the human experience celebrates curiosity and values every persons contributions to meaningful progress. That commitment has earned us recognition as Science magazines No.

1 Top Employer for five consecutive years certification as a Great Place to Work in the U.S. and a place on The Sunday Times Best Places to Work list in the UK.

For patients for each other and for the future of science were in. Are you

About the Role:

Were looking for an Early Development Program Lead to help us expand whats possible for patients with serious diseases. Reporting to the Chief Development Officer the Early Development Program Lead will serve as the scientific and operational leader for one or more early-stage drug development programs emerging from the Cambridge Research team.

This individual will be an experienced leader in the translational clinical science space. Serving as the critical bridge between discovery and development they will drive cross-functional project teams as they evolve from late-stage lead optimization through IND onboarding and engaging development functions to ensure scientific rigor strategic alignment and on-time delivery of program milestones.

Our research facility in Cambridge UK - a state-of-the-art hub on the Babraham Research Campus - is home to a world-class team pioneering a Synthetic Rescue drug discovery platform generating first-in-class small molecule and oligonucleotide therapeutics for diseases with no adequate treatment options.

What Youll Do:

In this role youll have the opportunity to serve as the primary bridge between the Cambridge Research organization and Insmeds Development functions; lead and coordinate cross-functional early development project teams spanning medicinal chemistry CMC formulation biology toxicology DMPK/ADME translational science regulatory clinical and patient advocacy. Youll also:

Project Leadership

• Provide strategic scientific project leadership and oversight for the cross-functionalteamto spearhead the definition ofprojectobjectives.

• Lead the definition and oversee execution of the scientific strategy for assigned small molecule and/or ASO programs from late lead optimization up to IND.

• Establish productive working relationships with CROs and CDMOs to ensure timely completion of outsourced activities partnering with relevant Insmed functions to identify assess and oversee.

• Integrate multi-disciplinary data to drive candidate selection decisions aligned with the Target Product Profile (TPP).

• Facilitate resource allocation and decision-making across functions with competing priorities and timelines.

• Set ambition and define & drive project strategy through key milestones; accountable forprojecttimeline and execution tofacilitatemeeting deliverables necessary for project continuation.

• Lead identification and management of key risks across scientific CMC and clinical domains including appropriate mitigation and contingency planning.

Project Management

• Work with Program Management to develop maintain and communicate integrated project plans timelines budgets and risk registers.

• Lead cross functional discussions to develop early TPPs.

• Facilitate team meetings drive decision-making and ensure accountability across functions; prepare and present program updates to senior leadership and governance committees.

• Proactively identify and communicate risks and develop mitigation strategies to keep programs on track.

• Collaborate with portfolio management to ensure alignment with corporate strategy.

• Oversee provision of updates to the Cambridge Development Program team to ensure timely awareness of approaching project needs and approaching development milestones.

Communication & Reporting

• Author and review key program documents including early TPPs project charters integrated development plans and support of any regulatory briefing documents; present program status and support presentations of scientific findings to internal leadership.

Who You Are:

You must have a PhD in Medicinal Chemistry Pharmacology Pharmaceutical Sciences Translational Medicine Biochemistry or a related discipline with direct relevance to small molecule or oligonucleotide drug discovery and development. Additionally you have:

• 15years of experience in the pharmaceutical/biotech industry with…