Advanced Sample Technician

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radio conjugates (BRCs) and imaging agents;; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle®technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
• We are One Team. We only succeed when we work together.

This is a fully onsite position based at our Cambridge, UK facilities. Given the laboratory-based nature of this role, daily onsite presence is required to work closely with our teams, access our cutting-edge resources, and drive our science and operations forward.

The Advanced Sample Technician will be a key member of the Compound Management team within Bicycle Therapeutics’ Scientific Operations Department, playing an essential role in the operational success of our sample archiving and delivery services. This position is responsible for the precise and timely processing, management, and distribution of valuable research samples from both internal and external sources.

As our team evolves by integrating new technologies, this role will be instrumental in the transition towards automated workflows. The ideal candidate will have a strong background in laboratory procedures, exceptional attention to detail, an interest in automation, and a proactive mindset to help shape the future of our sample management capabilities ensuring our scientists have reliable access to the materials they need to discover and develop innovative treatments for patients.

You will provide critical technician support for sample processing and preparation, which includes:

• Processing samples arriving from external CROs
  • Performing quality control checks
  • Uploading data to the LIMS database
  • Storing materials in an automated compound management store
• Processing samples from internal synthesis pipelines
  • Solubilizing solid peptides and preparing assay-ready samples using both automated liquid handlers and manual workflows
  • Storing both assay ready samples and stock batches
• Actioning requests from scientists via a ticketing system
  • Preparing custom sample aliquots for specific assays
  • Preparing sample sets for shipment to external partners
  • Liaising with the logistics team to prepare sample shipments in accordance with standard operating procedures and regulatory requirements
  • Liaising directly with scientists to discuss their support requirements.
• Ensuring that laboratories meet all Health and Safety requirements by keeping work spaces clean and tidy, writing and maintaining Standard Operating Procedures…