Principal Technical Project Manager ( office locations

Position: Principal Technical Project Manager ( we have office locations  amp )
Company Description

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.

Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.

We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.

We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime – from birth to old age.

Job Description

We are seeking a Principal Technical Project Manager to help deliver and enhance modern on-premise and cloud-based infrastructure supporting world-leading genomics diagnostics and research. In this role, you will work closely with the Scalable Service Lead and leadership team to guide multiple interdependent technical work streams, ensuring delivery aligns with programme objectives, governance frameworks, and PMO standards.
You will collaborate across squads, suppliers, and partners, while supporting the Service Owner in coordinating technical platform delivery and managing third-party contributions. This senior role suits someone with strong technical understanding, excellent stakeholder engagement skills, and experience delivering complex platforms in regulated or data-intensive environments, with a collaborative and inclusive approach to delivery.

Everyday responsibilities include:

Lead end-to-end delivery of key technical areas within the programme, taking ownership while fostering a collaborative, supportive delivery environment.
Partner with the Product Manager and/or Service Owner to validate and agree requirements, ensuring alignment with timelines, budgets, and OKRs.
Establish and maintain delivery plans, tracking progress and communicating clearly where adjustments or support are needed.
Proactively identify and resolve issues, working closely with teams to remove blockers and enable successful outcomes.
Create and manage RAID (Risks, Actions, Issues, and Dependencies) logs, regularly reviewing and coordinating follow-up actions.
Produce clear, concise status updates and contribute to programme and board-level reporting where required.
Support structured and inclusive decision-making processes, ensuring the right stakeholders are engaged at the right time.
Apply appropriate governance to meet internal and external standards, including cybersecurity, data protection, data quality, and regulatory requirements.
Ensure transparent, thoughtful communication so delivery teams understand priorities, timelines, and expectations, while keeping stakeholders informed.
Build positive relationships with internal and external stakeholders, managing escalations. constructively and facilitating respectful conflict resolution when needed.

Skills and experience for success:

Project, risk, and issue management with a proactive and solutions-focused approach.
Strong communication skills, engaging effectively with both technical and non-technical audiences.
Commercial awareness and financial understanding to support informed decision-making.
Stakeholder management, building trusted relationships across teams and leadership levels.
Confident decision-making with sound judgement on escalation and risk management.
Ability to translate complex…