IT Systems Analyst

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle® molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly BT5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; a pipeline of Bicycle® Radio conjugates (BRCs) and imaging agents;; zelenectide pevedotin (formerly BT8009), a BDC® targeting Nectin-4, a well-validated tumor antigen; and, through various partnerships, the use of Bicycle®technology to develop therapies to treat diseases in a range of therapeutic areas.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
• We are One Team. We only succeed when we work together.

WORKING CLASSIFICATION: Onsite

This is a fully onsite position based at our Cambridge, UK facilities. Given the collaborative and operational nature of this role, daily onsite presence is required to work closely with our teams, access our cutting-edge resources, and drive our science and operations forward.

As our Corporate IT team across the UK & US has evolved, we have created an exciting opportunity for an experienced IT Systems Analyst to join our UK team at Granta Park near Cambridge. This position will report to our Associate Director, IT Operations & Cyber Security and will be instrumental in supporting and advancing the IT systems throughout the organisation.

Your mission will be to ensure the reliability, security, and efficiency of our IT infrastructure, from user endpoints to our core server environment. You will be a key driver in maintaining our high standards of IT service, strengthening our cybersecurity posture, and delivering robust solutions that empower our scientific and operational teams across the UK and US.

Your responsibilities include (but not limited to):

• Frontline & Escalation Support:
  
  Act as a primary point of contact for IT support for UK colleagues and provide expert remote support globally, managing the helpdesk to ensure timely resolution of 1st and 2nd line tickets and appropriate escalation to maintain user satisfaction.
• User & Systems Administration:
  
  Manage the full employee IT lifecycle, including hardware/software setup for new joiners and secure off-boarding. Administer and troubleshoot critical server environments (Windows/Linux), virtualisation platforms (Hyper-V), and networking equipment to maintain a 99.9% uptime.
• Security & Operational Excellence:
  
  Collaborate with IT leadership to advance our cybersecurity posture by implementing and managing security tools (e.g., Darktrace, Mimecast), supporting enterprise security and disaster recovery drills, and diligently documenting all systems and processes to create a robust knowledge base.
• Continuous Improvement & Project Delivery:
  
  Proactively identify opportunities to streamline, upgrade, and integrate IT systems. Lead and contribute to IT project work, from scoping to delivery, ensuring solutions are implemented on time and within budget to…