Immunoassay Senior Scientist

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No.

1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we’re in. Are you?

We are seeking a highly experienced, industry-trained Senior Scientist specialising in immunoassay development to join our evolving drug discovery team at Insmed Cambridge. This is an exciting, lab-based opportunity for an innovative and motivated assay scientist with deep expertise in novel immunoassay design, supporting a wide range of projects in our portfolio.

Operating within our Drug Discovery Biology team and sitting within the Compound Profiling group, you will be accountable for designing, implementing, and delivering robust immunoassay data to support screening cascades that enable the progression of small molecule and oligonucleotide therapeutics from early target feasibility and Hit Finding, through to Candidate Nomination.

You will act as our core subject matter expert for immunoassays, taking ownership of experimental design and data generation. Applying a rigorous, industry-standard approach, you will develop novel, highly sensitive assays to deliver high-quality, reproducible bioanalytical data that informs project progression. You will collaborate closely with interdisciplinary teams to translate new biological insights into life-changing therapeutics.

• Collaboratively design, implement, and interpret immunoassay data as part of screening cascades to advance drug discovery programs.
• Perform hands-on development, optimisation, validation, and troubleshooting of highly sensitive singleplex and multiplex immunoassay formats (e.g., ELISA, HTRF, AlphaLISA, MSD, Luminex) to assess target engagement, pathway modulation, and mechanism-of-action.
• Apply strong pharmacological expertise and early-stage, fit-for-purpose method validation principles to optimise assay performance parameters to generate robust, decision-enabling pharmacodynamic and target engagement data.
• Generate high-quality data to characterise novel small molecule and oligonucleotide therapeutics, informing structure-activity relationships and compound progression criteria.
• Support early pharmacokinetic, pharmacodynamic, and immunogenicity assessments to drive Lead Optimisation and candidate selection.
• As part of the Compound Profiling Team, maintain the flexibility to run broader in vitro compound profiling assays (e.g., standard biochemical or cellular screens) to support the team s overall screening cascades and workload.
• Oversee data generation conducted at external vendors/CROs via scientific monitoring, critically appraising scientific quality, data interpretation, and timely delivery.

• Contribute to a high-performing Compound Profiling team, acting as the core subject matter expert for immunoassays and drug discovery cascade target engagement and pharmacodynamic marker data across the early Discovery portfolio.
• Provide broad, hands-on support for general compound profiling activities to drive DMTA cycles, partnering with Chemistry, DMPK, and project teams to ensure assays align with project milestones and accelerate informed compound progression.
• Support, mentor, and develop junior scientists in immunoassay techniques and troubleshooting (with the potential for formal line management responsibilities depending on experience), promoting professional growth, knowledge-sharing, and a collaborative laboratory culture.

• Continuously enhance in-house experimental capabilities by proactively identifying,…