Research Scientist, in vivo Pharmacology-Oncology

Job Description Summary Are you a scientist who combines strong hands-on in vivo pharmacology expertise with independent scientific thinking? In this role, you will design and lead preclinical oncology studies to investigate drug exposure, target engagement, pharmacodynamic responses and anti-tumor efficacy. You will integrate in vivo and ex vivo data to address key scientific questions and provide actionable recommendations to multidisciplinary drug discovery teams.

Location:

Cambridge, USA #LI-Onsite This role is based in Cambridge, USA. Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.

Job Description Responsibilities:

Independently design, plan and execute preclinical in vivo oncology studies to test scientific hypotheses, evaluate candidate medicines and inform project decisions.

Perform animal procedures such as dosing, tumor implantation, monitoring and sample collection, following procedures and welfare requirements.

Establish, characterize and critically select relevant tumor models for efficacy and pharmacokinetic/pharmacodynamic studies.

Define study objectives and experimental strategies, including dose selection, treatment schedules, controls and pharmacodynamic sampling plans.

Develop, optimize and troubleshoot protein-based pharmacodynamic assays, including MSD, ELISA and Western blot, to assess target engagement and pathway modulation.

Design and interpret RNA-based gene-expression analyses alongside protein measurements to investigate pharmacodynamic and biomarker responses.

Oversee robust tumor and normal tissue processing and optimize sample preparation and assay workflows to ensure reliable downstream analyses.

Critically integrate efficacy, drug exposure and pharmacodynamic datasets to evaluate exposure–response relationships, identify limitations and recommend next experiments.

Record experiments accurately and promptly in the electronic laboratory notebook.

Communicate scientific conclusions, study limitations and data-driven recommendations to cross-functional project teams through presentations and study reports.

Essential for the role:

Bachelor's or Master's degree in pharmacology, biology, cancer biology, molecular biology or a related scientific subject.

Relevant industry or academic research experience demonstrating scientific independence and expertise appropriate for a Scientist role.

Strong hands-on experience with mouse studies, including dosing, tumour implantation, animal monitoring and sample collection.

Hands-on experience with protein-based assays such as Meso Scale Discovery assays, enzyme-linked immunosorbent assays or Western blot.

Demonstrated ability to independently design, execute, analyze and troubleshoot in vivo pharmacology studies, beyond following established study plans.

Strong attention to detail and organizational skills.

Strong scientific judgement, with the ability to translate biological questions into testable hypotheses and fit-for-purpose experimental designs.

Ability to interpret complex datasets, communicate clear scientific conclusions and collaborate effectively with Biology, DMPK/PK and other disciplines.

Desirable for the role:

Experience with oncology models (xenograft, patient-derived xenograft or syngeneic), integrated in vivo efficacy and PK/PD studies, and RNA-based pharmacodynamic analyses.

Strong understanding of PK/PD principles and exposure–target engagement–efficacy relationships; proficiency with Graph Pad Prism or equivalent quantitative analysis tools.

Benefits & Rewards:

At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.

Expected Annual Base Salary Range for role: $57,750 to $107,250

The base salary…