France – PhD in Immunopathology and Structural Biology at University of Limoges

University: University of Limoges

Country: France

Deadline: Not specified

Fields: Immunology, Biochemistry, Structural Biology, Cancer Biology, Pathophysiology

Are you passionate about understanding the molecular mechanisms underlying rare and devastating diseases, and eager to contribute to cutting‑edge research at the intersection of immunopathology, cancer biology, and structural biology?

France continues to stand as a beacon of scientific excellence and academic innovation, attracting the brightest minds from around the globe. The University of Limoges, in collaboration with leading French research institutions such as CNRS and INSERM, offers a vibrant and multidisciplinary environment for doctoral research. With its rich cultural heritage, high quality of life, and strong investment in scientific infrastructure, France is an ideal destination for aspiring researchers seeking to launch their careers in biomedical sciences.

The University of Limoges, located in the heart of the Nouvelle‑Aquitaine region, is renowned for its commitment to fostering innovation, supporting young scientists, and advancing impactful research in the life and medical sciences.

The university is committed to supporting early‑career researchers through state‑of‑the‑art facilities, mentorship, and a collaborative environment that encourages scientific curiosity and innovation.

The University of Limoges is a distinguished French public university known for its dynamic research ecosystem and strong partnerships with national research bodies, including CNRS (Centre National de la Recherche Scientifique) and INSERM (Institut National de la Santé et de la Recherche Médicale). The doctoral fellowship is based within the CRIBL laboratory (CNRS UMR
7276 – INSERM UMR
1262), a hub of interdisciplinary research excellence in Limoges. The city itself offers a high quality of life, a welcoming academic community, and proximity to France’s major scientific centers.

This doctoral fellowship focuses on the investigation of rare disorders caused by abnormal monoclonal immunoglobulin fragments, a field with significant implications for both fundamental and clinical research. These disorders, such as AL amyloidosis, are not only devastating for patients but also present complex scientific challenges that require innovative approaches. The project integrates immunopathology, cancer biology, structural biology, and the study of cardiac and renal pathophysiology.

Understanding the mechanisms by which monoclonal immunoglobulin fragments drive disease progression can open new avenues for diagnosis, treatment, and prevention. The research is highly relevant in today’s context, where rare diseases are increasingly recognized as critical frontiers in biomedical science.

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The successful PhD candidate will join the BioPIC team, which is dedicated to unraveling the molecular and cellular mechanisms of rare immunoglobulin‑related disorders. The project will leverage newly developed mouse models of AL amyloidosis (both kappa and lambda light chain variants), as recently described in Martinez‑Rivas et al., Nature Communications, 2025. The research will employ a comprehensive suite of methodologies, including recombinant protein production, structural protein modeling, animal experimentation, bulk and spatial transcriptomics, mass spectrometry, and tissue imaging.

The candidate will gain hands‑on experience with cutting‑edge technologies and contribute to high‑impact publications in the field.

The ideal applicant is a motivated, curious, and brilliant individual with a strong academic background and a passion for biomedical research. While prior experience in biochemistry,…