Senior Scientist, In Vivo Pharmacology; Radiopharmaceuticals

Job Description

Your mission is to apply your deep expertise in in vivo pharmacology to drive the preclinical evaluation of our innovative Bicycle Radio Conjugates (BRCs). By independently executing and interpreting key preclinical studies, you will generate the critical data needed to understand their activity, guide their optimization, and support the advancement of our next-generation cancer therapies.

Working location: This role can initially be based remotely, with a requirement to travel to the Cambridge office once per week. We estimate that from early 2027 the position will have a hybrid attendance at our office in London (up to 4 days per week),in the vicinity of Kings Cross, with an ongoing requirement to visit the Cambridge Office up to 2 days per month.

• Take a leading role in the design, execution, and interpretation of in vivo pharmacology studies to evaluate the biodistribution, mechanism of action, and PK/PD/efficacy relationships of our BRCs.
• Manage the execution of in vivo studies through a network of CROs and academic collaborators, ensuring timely delivery of high-quality data.
• Act as a key technical expert on cross-functional project teams, collaborating with chemistry, biology, DMPK, and toxicology experts to contribute to project goals.
• Contribute to the identification and validation of pharmacodynamic biomarkers to support preclinical and clinical development.
• Perform hands‑on in vivo experimental work as required to support project progression and ensure timely data delivery

• Effectively document and communicate complex study results and their interpretation to project teams and in broader scientific forums.
• Contribute to publications for peer‑reviewed journals and present data at scientific conferences.
• Act as a source of technical expertise for the team, sharing best practices in in vivo techniques and radiopharmaceutical handling.

• Core Expertise: You apply strong expertise in in vivo pharmacology to independently design and execute complex preclinical experiments.
• Data / Insight: You independently interpret complex in vivo data from imaging and ex vivo analysis, drawing clear conclusions to inform project decisions.
• Knowledge Sharing: You build collective expertise by actively sharing your learnings, documenting methods, and helping colleagues solve technical problems.

• Task / Project Delivery: You independently deliver work of moderate to high complexity, taking ownership of critical in vivo work streams that are essential to project milestones.
• Problem‑Solving: You develop practical and creative solutions when scientific or technical challenges arise in your studies, adapting established methods to address them.
• Strategic Impact
  :
  You provide the key data and scientific insights that directly inform project decisions and help the team prioritize its next steps.

• Autonomy: You operate with a high degree of independence in your daily research, requiring only general instructions on new projects or assignments.
• Decision‑Making: You select suitable study designs and analytical methods with sound scientific judgment to ensure the quality and reliability of your results.
• Leadership / Mentorship: You act as an informal mentor to junior colleagues, sharing your technical expertise and providing guidance on best practices.

• Collaboration: You work proactively across functions, building strong relationships to ensure your in vivo work is well‑integrated with other project activities.
• Inclusive Leadership: You encourage diverse input and open dialogue, actively listening to different scientific perspectives to improve your work.
• Mentorship / Support: You actively coach less experienced team members, sharing your knowledge of specific in vivo techniques and scientific principles.

• Innovation: You propose creative solutions to scientific challenges and are keen to trial new techniques or models within your projects.
• Risk‑Taking: You challenge established methods constructively, suggesting alternative…