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Principal Scientist - Pharmaceutical Development

Job in Centurion, 0014, South Africa
Listing for: Placements24
Full Time position
Listed on 2026-10-05
Job specializations:
  • Pharmaceutical
    Pharmaceutical Science/ Research, Pharmaceutical Manufacturing, Drug Discovery
Job Description & How to Apply Below
About the Role

Our client is seeking an accomplished Principal Scientist to lead key initiatives within their Pharmaceutical Development division located in Centurion . This senior role is instrumental in guiding the formulation, process development, and scale-up of innovative drug candidates from early-stage research through to clinical trials. You will leverage your deep expertise in pharmaceutical sciences to solve complex development challenges, mentor a team of scientists, and ensure the successful translation of scientific discoveries into viable pharmaceutical products.

This position is ideal for a seasoned professional looking to make a substantial impact in a fast-paced, research-intensive environment.

Key Responsibilities
  • Lead the design, execution, and interpretation of formulation development studies for novel drug delivery systems.
  • Develop and optimize manufacturing processes for drug substances and drug products, ensuring scalability and regulatory compliance.
  • Troubleshoot complex technical issues encountered during formulation and process development activities.
  • Collaborate closely with analytical development, quality control, and regulatory affairs teams to ensure seamless project progression.
  • Mentor and guide junior scientists and technicians, fostering a culture of scientific rigor and continuous improvement.
Requirements
  • Ph.D. in Pharmaceutical Sciences, Chemical Engineering, or a closely related discipline.
  • Minimum of 8 years of relevant experience in pharmaceutical research and development, with a strong focus on formulation and process science.
  • Extensive knowledge of drug delivery technologies, solid-state chemistry, and manufacturing principles (e.g., GMP).
  • Proven track record of successfully advancing drug candidates through the development pipeline.
  • Exceptional problem-solving abilities and strong leadership skills.
Benefits
  • Highly attractive salary and comprehensive bonus structure.
  • Premium healthcare, dental, and vision coverage.
  • Generous contributions to retirement savings plans.
  • Extensive professional development and training opportunities.
  • Collaborative and innovative work environment in Centurion , with hybrid work flexibility.
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