UNIV - Postdoctoral Fellow - Department of Biochemistry

Job Description Summary

The Department of Biochemistry & Molecular Biology at the Medical University of South Carolina (MUSC) invites applications for a Postdoctoral Fellow position in the laboratory of Dr. Huimin Zhang, who joined MUSC in November 2025. The Zhang Lab focuses on DNA damage repair and cancer biology, investigating the molecular mechanisms underlying genomic instability and developing strategies to exploit these mechanisms for cancer therapy.

Research emphasizes tumor suppressor genes, oncogenes, and other genes involved in DNA damage response pathways that contribute to tumor initiation, progression, and metastasis. The lab particularly studies how cells respond to chemotherapy and maintain genomic stability, with a focus on topoisomerase‑targeting agents (Molecular & Cellular Proteomics, 2025, DOI: 10.1016/j.mcpro.;
Science Advances, 2023, DOI: 10.1126/sciadv.adi
6681;
Nature Communications, 2022, DOI: 10.1038/s-7;
Nucleic Acids Research, 2019, DOI: 10.1093/nar/gkz
769;
Journal of Biological Chemistry, 2016, DOI: 10.1074/jbc.

M. The lab employs a broad range of biochemical, molecular, and cellular approaches, including large‑scale proteomics and genome‑wide CRISPR/Cas9 screening to explore cancer‑related protein–protein, gene–gene, and gene–drug interactions. We seek applicants who are self‑motivated, career‑oriented, and enthusiastic to join an exciting and highly interactive research team.

The Postdoctoral Fellow will lead and conduct independent research projects under the supervision of the Principal Investigator (PI), contribute to manuscript preparation and publication, and participate in project management, grant writing, and career development activities. The fellow will collaborate closely with the PI and lab members in all aspects of research.

• Self‑motivated and career oriented.
• Strong background in biochemistry, molecular biology, and cell biology.
• Hands‑on experience with molecular and cellular biology.
• Proven ability to design, execute, and analyze experiments independently.
• Excellent organizational, written, and oral communication skills.
• Demonstrated publication record in peer‑reviewed journals.
• Ability to work collaboratively within a multidisciplinary research team.
• Creative thinking, attention to detail, and commitment to scientific rigor.

• Experimental design and execution (35%) – Design and conduct experiments using state‑of‑the‑art biochemical, molecular, and cellular approaches to study DNA repair mechanisms and chemotherapy response.
• Data analysis and interpretation (35%) – Collect, organize, and analyze experimental data; maintain detailed laboratory records and ensure data integrity; interpret findings and plan follow‑up experiments.
• Manuscript and grant preparation (20%) – Prepare figures and text for publications and grant proposals; contribute to writing manuscripts, abstracts, and reports; present findings in lab meetings, departmental seminars, and scientific conferences.
• Laboratory maintenance and compliance (10%) – Assist in maintaining laboratory organization, equipment, and supply inventories; ensure compliance with institutional safety and regulatory policies.

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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