Research Scientist - Song Lab

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The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary Summary The  Song Lab at Massachusetts General Hospital and Harvard Medical School investigates the molecular mechanisms underlying neurodegenerative diseases, including Alzheimer’s disease, ALS/FTD, and Huntington’s disease. Our research integrates mechanistic neurobiology, human iPSC-derived neuronal models, advanced imaging, proteomics, and emerging AI-enabled technologies to understand how disease-associated proteins disrupt neuronal function and to translate these discoveries into novel biomarkers and therapeutic strategies.

The successful candidate will join a highly collaborative and interdisciplinary research environment spanning basic and translational neuroscience, structural biology, and AI-driven protein design. A major focus of this position will be a collaborative project evaluating AI-assisted de novo protein designs targeting pathological forms of amyloid-β, tau, and TDP-43, with the goal of developing new tools for disease detection and therapeutic intervention.

Candidates with expertise in one or more of the following areas are particularly encouraged to apply: protein biochemistry, cellular and animal models of neurodegeneration, human tissue processing and analysis, advanced microscopy, and multi-omics approaches. Experience working across disciplines and an interest in translating mechanistic discoveries into biomarkers and therapeutics are highly  consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication.

Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.

Does this position require Patient Care? No

Essential Functions-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.

-Contributes to the design and execution of experiments and/or research projects.

-Exercises judgment in selecting methods and technologies to obtain results.

-May collaborate with external researchers and/or receive external project funding support.

-Presents results and prepares publications.

-May assist PI in the training and supervision of other staff.

Qualifications Education
Doctorate Related Field of Study required

Can this role accept experience in lieu of a degree?
No

Licenses and Credentials

Experience
Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required

Knowledge,

Skills and Abilities

- Excellent research skills.
- Demonstrated evidence of specific scientific competence in field.
- Demonstrated broad knowledge of field.
- Evidence of potential for scientific creativity and original though.
- Able to exercise independent judgment and leadership.
- Ability to contribute to publications.

Additional Job Details (if applicable)$60,000-$96,000

Remote Type Onsite Work  Location
114 16th Street Scheduled Weekly Hours
40

Employee Type Regular Work  Shift Day (United States of America)
EEO Statement:1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable…