Principle IT Project Manager

Piper Companies is supporting recruiting efforts for one of the world's largest clinical research organizations seeking a Principal IT Project Manager who will work fully remote in EST hours
. The ideal Principal IT Project Manager will lead large-scale technology initiatives, partnering with business and technical teams to ensure projects are delivered on time, within budget, and aligned with organizational goals in a highly regulated environment.

• Lead multiple complex IT projects from planning through implementation and post-launch support.
• Build and manage project plans, timelines, budgets, and resource allocations.
• Coordinate cross-functional teams including Product, Engineering, Infrastructure, Security, and Operations.
• Provide regular project updates, status reports, and recommendations to senior leadership.
• Facilitate governance meetings, steering committees, and stakeholder reviews.
• Identify project risks, dependencies, and issues, developing mitigation and recovery plans as needed.
• Ensure project documentation, approvals, and deliverables are maintained in accordance with company standards.
• Manage project scope, change requests, and competing priorities while maintaining delivery commitments.
• Support portfolio planning efforts by helping prioritize initiatives and align resources.

• 8+ years of experience managing enterprise-level IT projects or programs.
• Must be eligible to work in the United States and obtain and maintain an Active U.S. Government Secret Clearance.
• Proven success delivering large, complex technology initiatives involving multiple teams and stakeholders.
• Strong knowledge of Agile, Waterfall, and hybrid project management methodologies.
• Experience leading projects in regulated industries such as life sciences, healthcare, pharmaceutical, biotechnology, or clinical research.
• Proficiency in project management tools such as Jira, Azure Dev Ops, Smartsheet, MS Project, and Service Now
• Strong experience with risk management, issue resolution, dependency tracking, and change management.
• PMP, PgMP, SAFe, MSP, or similar certification preferred.
• Knowledge of GxP or validated technology environments is a plus.
• Bachelor's degree in Information Technology, Business, Engineering, Life Sciences, or a related field.

• Salary range: $130,000 - $170,000 base salary depending on experience
• Comprehensive benefits package including medical, dental, vision, 401(k), PTO, and additional company-sponsored benefits

This job opens for applications on 10/15/2026. Applications for this job will be accepted for at least 30 days from the posting date.

#LI-BR1

#LI-REMOTE