Research Scientist, Karthick Lab, COM, Division of Cardiovascular Biology, Metabolism & Pharmacology

Research Scientist, Karthick Lab, COM, Division of Cardiovascular Biology, Metabolism & Pharmacology

Job Description

Job Title:

Research Scientist, Karthick Lab, COM, Division of Cardiovascular Biology, Metabolism & Pharmacology Posting

Start Date:

10/19/26 Work Arrangement:
Onsite

Next Lives at the University of Cincinnati

Founded in 1819, the University of Cincinnati ranks among the nation’s best urban public research universities. Home to more than 53,600 students, 12,000 faculty and staff, and over 360,000 living alumni, UC, a Carnegie 1 institution, combines research prowess with a physical setting The New York Times has called “the most ambitious campus design program in the country." UC's momentum has never been stronger as the anchor of the Cincinnati Innovation District, the oldest cooperative education (co-op) program in the country with students earning $94 million annually through paid experiences, an academic health system, and as a member of the Big 12 Conference.

The university contributes $10.6 billion in economic impact to the city and $22.7 billion to the state of Ohio. At UC, next is all of us. Learn more  .

UC is a mission-driven organization where we are committed to student success and positively transforming the community through scholarship and service. We thrive on innovation, making an impact, and fostering an environment where staff and faculty are key contributors to UC’s success.

As one of the oldest medical schools in the country, the UC College of Medicine has a reputation for training best-in-class health care professionals and developing cutting-edge procedures and research that improves the health and clinical care of patients.

A Research Scientist position is available in the laboratory of Dr. Karthick Chella Krishnan ( www.med.uc.edu/klab ) in the Department of Basic Biomedical Sciences, Division of Cardiovascular Biology, Metabolism and Pharmacology, at the University of Cincinnati College of Medicine. The K Lab conducts mechanistic research at the intersection of mitochondrial biology, metabolism, genetics, and sex differences, with projects spanning the liver, adipose tissue, heart, and hippocampus.

The laboratory focuses on understanding how genetic background and sex shape mitochondrial adaptation and dysfunction and contribute to cardiometabolic disease. Current research areas include mitochondrial subpopulations, sex-dependent metabolic regulation, genetic determinants of mitochondrial function, and organ-to-organ communication.

• Perform in-depth studies of mitochondrial function and metabolism using isolated liver mitochondria, primary or immortalized liver cells, human iPSC-derived hepatic organoids, and mouse models.
• Elucidate the molecular mechanisms regulating mitochondrial function and metabolism in metabolic and cardiometabolic disease using a combination of biochemical, molecular, cellular, and mouse genetic approaches.
• The goal of this research is to understand how alterations in mitochondrial function and metabolism contribute to disease pathogenesis and to identify mechanisms that may provide new insights into therapeutic approaches for the improvement of human health.

Daily tasks will include:

• Independently designing and conducting research as required by the faculty supervisor and in accordance with all institutional and federal regulations;
• Modifying and adapting experimental protocols (i.e., troubleshooting), techniques and procedures to address project-specific experimental challenges and requirements;
• Supporting the development of proposals and writing research-related funding and grants;
• Analyzing and interpreting data, preparing research results and written summaries in manuscript form for publications and…