Postdoctoral Research Fellow; Grimes; Immunobiology

Primary Location
Location S Department
Immunobiology Shift
Day (United States of America) Schedule
Full time Weekly Hours
40 FTE
1 Employee Status
Regular

The Grimes Lab at Cincinnati Children's Hospital Medical Center is seeking a highly motivated Postdoctoral Fellow to join a collaborative research program focused on hematopoiesis, response to infection, and molecular oncology. Led by H. Leighton "Lee" Grimes, PhD , the lab investigates the molecular and cellular mechanisms that regulate normal and malignant hematopoiesis, with particular emphasis on myelopoiesis, bone marrow failure syndromes, myelodysplastic syndromes (MDS), severe congenital neutropenia (SCN), and acute myeloid leukemia (AML) .

Our goal is to uncover fundamental biological and molecular mechanisms underlying these diseases and translate those discoveries into new opportunities for therapeutic intervention.

The successful candidate will have the opportunity to conduct innovative research using established and emerging approaches, including:

• Mouse models of normal and malignant hematopoiesis
• Molecular and cellular studies of hematopoietic development and differentiation
• Single-cell RNA sequencing and other advanced single-cell technologies
• Transcriptional and epigenetic profiling
• Multi-omics approaches to normal and malignant hematopoiesis
• Investigation of MDS, SCN, AML, and other bone marrow disorders
• Development and evaluation of small-molecule and RNA-based therapeutic approaches

A particular strength of the program is its integration of wet-lab experimental biology with computational and bioinformatics approaches . Through collaboration and mentorship with Nathan Salomonis, PhD , trainees have opportunities to develop expertise in analyzing complex single-cell and multi-omics datasets.

The Grimes Lab has a strong track record of developing and applying innovative approaches to hematopoietic biology. The laboratory has established multiple mouse models of human disease, including AML and SCN, and has contributed to advances in understanding hematopoietic differentiation, RNA splicing, epigenetic regulation, and disease-associated mutations. In collaboration with the Salomonis Lab, the team also develops biologically focused informatics tools and workflows for the analysis and visualization of single-cell data.

Postdoctoral fellows will work in a highly collaborative, multidisciplinary environment that provides opportunities to build expertise in both experimental and computational research while contributing to discoveries with potential therapeutic relevance.

• A PhD, MD, MD/PhD, or equivalent doctoral degree in a relevant scientific discipline
• A strong background in molecular biology, cell biology, hematology, cancer biology, immunology, genetics, genomics, bioinformatics, or a related field
• Demonstrated interest in hematopoiesis, leukemia, bone marrow disorders, molecular oncology, or related areas
• Strong analytical, problem-solving, and scientific communication skills
• The ability to work independently and collaboratively in a multidisciplinary research environment
• Experience with mouse models, molecular biology techniques, single-cell sequencing, genomics, epigenetics, computational biology, or bioinformatics is desirable.

• Develop expertise in both wet-bench and computational approaches
• Gain experience with advanced single-cell and multi-omics technologies
• Participate in collaborative and translational research
• Present findings at scientific meetings and contribute to peer-reviewed publications
• Develop scientific writing, communication, and independent research skills
• Build a foundation for an independent career in biomedical research

The Grimes Lab is committed to developing a comprehensive understanding of normal and malignant hematopoiesis and using those insights to identify new approaches to treating hematologic disease. The lab's work spans basic biology, disease modeling, genomics, bioinformatics, and therapeutic development, providing postdoctoral fellows with a multidisciplinary environment for scientific training and career development.

• Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist
• Design, execute, and record laboratory experiments, and analyze data, which may affect…