Clinical Development Medical Director- Vascular

Position Summary

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success.

We're uniting science, technology, and talent to get ahead of disease together.

The Clinical Development Medical Director provides clinical and scientific insights and leadership to clinical and translational studies or programs that modulate vascular biology and pathology within the Early Pipeline Unit (EPU) of the Respiratory, Immunology and Inflammation Research Unit (RIIRU). The appointed individual will be a subject matter expert in disease driven by vascular pathology.

You will work within project teams to plan, execute, and deliver activities including translational and clinical development strategies and clinical studies across a range of therapy areas with a focus on disease driven by systemic inflammation and endothelial dysfunction. You will work cross‑functionally to develop and execute clinical development plans up to and including proof‑of‑mechanism/proof‑of‑concept studies.

• Provide scientific and clinical leadership to strengthen RIIRU's capabilities in translation and early clinical development programs that modulate inflammation and endothelial dysfunction using a range of drug modalities, including oligonucleotides, biologics and small molecules.
• Act as a subject matter expert in clinical development drugs that modulate inflammation and endothelial dysfunction.
• Support the design of translational and clinical plans that support project strategy. Support the execution of high‑quality evidence‑gathering and clinical development plans that offer swift paths to new safe and effective medicines. Lead development of clinical sections of core regulatory documents.
• Contribute to the design and execution of clinical studies that generate the data and evidence required to determine a target or medicines' potential efficacy, safety profile, key areas of product differentiation and route to becoming a medicine with value to patients in the shortest possible timeframe.
• Seek, build and maintain relationships with program counterparts in biology, translational, commercial, research technologies, regulatory affairs, clinical operations, market access, medical affairs and statistics.
• Contribute to the implementation and embedding of strategic initiatives and various organizational initiatives in clinical development.
• Provide effective support and oversight of R&D evidence generation activities to assure patient safety and study delivery.
• Contribute to study team discussions on indication planning, incorporating input from across disciplines to contribute to vital deliverables including early medicine profile, target validation, translational plans, candidate selection.
• Design clinical development plans and study protocols across all phases of development – with a focus on phases 1 and 2 – reflecting internal and external stakeholder input.
• Develop other asset‑and study‑related documents, including protocol amendments, investigator brochures, clinical study reports.
• Provide clinical input to regulatory interactions and documents and responses to regulatory feedback for assigned studies and programs.
• Provide medical monitoring and oversight of the safety of study participants on behalf of the sponsor during the study, together with pharmacovigilance physician. If you are a physician, this includes accountability for medical governance across the project to ensure scientific integrity and overall safety of the study participants.
• Be accountable for leading the clinical matrix team (CMT) on EPU programs. Serve as a clinical point of contact internally and externally for one or more asset or…