Senior Director, Global Program Management Oncology

Site Name: USA - Pennsylvania - Upper Providence, USA - Massachusetts - Boston

Posted Date:
Dec 18 2025

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

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Our approach to R&D

As the Senior Director of Program Management Oncology for a flagship oncology asset, you will be the driving force behind flawless execution—translating strategy into action and ensuring disciplined delivery of program milestones. You will shape critical decisions by influencing stakeholders through data‑driven insights and external perspectives, while fostering a culture of accountability and agility. Your role demands operational rigor, proactive risk management, and the ability to challenge assumptions to accelerate progress without compromising quality or safety.

Acting as the Medicine Development Leader’s strategic partner and primary point of contact for the program’s Medicine Development Team (MDT), you will oversee a complex, multi‑tumor program—integrating clinical development, asset and evidence strategies into a unified vision. You will lead all project management aspects of this high‑visibility initiative, ensuring milestone delivery at pace while upholding quality and safety. This involves:

Integrating clinical, regulatory, CMC, and commercial strategies into a unified program plan; guiding strategic discussions and encouraging diverse viewpoints to reach actionable outcomes; leveraging insights from external experts and benchmarks; and maintaining an overview of systems to identify dependencies and managing complexity.

This requires questioning assumptions, exploring new approaches through insightful inquiries; simplifying complex topics into actionable insights for senior leaders; and working with Medicine Development Leaders to optimize asset strategy considering both business and patient needs.

An important aspect of this role involves promoting team adaptability to evolving data and priorities, leading scenario planning to minimize disruption while staying aligned with long-term objectives and clearly communicating changes to keep program goals in focus.

Responsibilities include taking ownership of program execution, proactively resolving challenges, leading planning and risk management, tracking progress, identifying opportunities for innovation and efficiency, and accelerating outcomes by streamlining decision‑making and removing obstacles.

This role encompasses engaging with senior leaders, governance bodies, external partners, and subject matter experts; leading tailored meetings that enable decisive outcomes; cultivating trusted relationships and influencing through credibility, data‑driven insights, and composure; and ensuring program visibility through compelling storytelling and impactful dashboards.

The role requires facilitating governance interactions and translating complexity into clear, data‑driven recommendations; summarizing strategy, risks and options for decision‑making; balancing scientific rigor, operational feasibility and commercial value; and serving as the single point of accountability for program operations, performance and budget.

This role involves people management, therefore mentoring project managers, fostering ownership and high standards; and demonstrating calm and confident…