Senior Scientist, PBPK

# Senior Scientist, PBPK
* 15877
* * Contract*£18 Per Hour Site Based Kent, United Kingdom Updated on: 13-09-2026

Apply Now We are currently looking for a Senior Scientist, PBPK with expertise in Biopharmaceutics Modelling & Simulation to join a leading Pharmaceutical company in Kent, supporting drug development across all stages. This is an exciting opportunity for a highly motivated professional to contribute to innovative projects by applying mechanistic modelling approaches to predict in vivo drug performance and optimize formulations.
Based within a dynamic, multidisciplinary environment, you will collaborate closely with scientists across biopharmaceutics, formulation development, clinical pharmacology, and pharmacokinetics, leveraging your expertise to support model-informed decision-making and regulatory submissions.
This is an initial 12 month contract with possible extension.

** KEY DUTIES AND RESPONSIBILITIES
** Your duties as the Senior Scientist, PBPK will be varied however the key duties and responsibilities are as follows:
* As the Senior Scientist, PBPK, you will develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, Gastro Plus, or equivalent software.
* As the Senior Scientist, PBPK, you will support prediction and assessment of oral absorption, food effects, bioavailability, formulation bridging, dissolution, and particle size specifications, including virtual bioequivalence.
* As the Senior Scientist, PBPK, you will perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to inform project decisions.
* As the Senior Scientist, PBPK, you will collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and validation.
* As the Senior Scientist, PBPK, you will support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
* As the Senior Scientist, PBPK, you will communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
* As the Senior Scientist, PBPK, you will contribute to advancing modelling methodologies, automation, and integration of AI/ML-enabled predictive tools.

** ROLE REQUIREMENTS
** To be successful in your application to this exciting role as the Senior Scientist, we are looking to identify the following on your profile and past history:  
* A Degree or higher level in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or a related scientific discipline.
* Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
* Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
* Experience with PBPK/PBBM modelling software such as Simcyp, Gastro Plus, PK-Sim, or similar platforms.
* Evidence of proven ability to apply modelling solutions to pharmaceutical development challenges.

Key Words:
Senior / Scientist / Biopharmaceutics / Modelling / Simulation / PBPK / PBBM / Pharmacokinetics / Regulatory / Drug Development / Modelling / Modeling / Drug Product / Mechanistic Modelling / Pharmacokinetics / Drug Discovery / Simcyp / Gastro Plus / PK-Sim / Python / MATLAB / R Programming