Senior​/Lead Bioinformatics Scientist; Multi-Cancer Early Detection

Natera’s Research team is building tests that can detect many cancers from a single blood draw. We are looking for a Senior or Lead Bioinformatics Scientist to join the team building the technology at the heart of that effort. You will work with large-scale, multi-modal genomic datasets from clinical cohorts and partner closely with molecular biologists and clinical scientists. You will help advance the state-of-the‑art and drive new methods from prototype, through scalable implementation, toward clinical validation and, ultimately, to patients.

• Develop and validate new algorithms to analyze large multimodal epigenomic datasets
• Drive research analyses through implementation, testing and performance evaluation, including developing new features within existing pipelines
• Work with sequencing and clinical data from large cohorts, ensuring data integrity and quality control
• Partner with molecular biologists and clinical scientists to solve challenging, open-ended problems
• Visualize results and present complex findings to both technical and non-technical audiences
• Contribute to the team’s standards for code quality and reproducibility

• Ph.D. in Bioinformatics, Computer Science, Biology, or a related field; alternatively a Bachelor’s or Master’s degree with at least 4 years of professional experience
• Track record developing and validating analysis workflows for high-throughput sequencing data
• Experience applying and evaluating statistical and ML methods to large datasets
• Strong quantitative reasoning and data analysis skills, applied effectively to real scientific problems.
• Software development experience, including proficiency in Python and its scientific computing ecosystem
• Fluent using Linux command-line tools and cloud computing environments
• Strong verbal and written communication skills

• Working knowledge of DNA methylation and other epigenomic data
• Experience with cell-free DNA and liquid biopsy samples
• Background in cancer genomics or diagnostics
• Experience working with data and metadata from large clinical cohorts
• Familiarity using AI tools for complex scientific tasks and with foundation models applied to biological data

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $119,000-$163,000 USD

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits…