Research Scientist, Cancer Biology, Levi Lab

Overview

Job Description - Research Scientist, Cancer Biology, Levi Lab (250000R7)

Job Description

Research Scientist, Cancer Biology, Levi Lab - ( 250000R7 )

With over 75 years of excellence in Dallas-Fort Worth, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report, we invest in you with opportunities for career growth and development to align with your future goals.

Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you ll discover a culture of teamwork, professionalism, and a rewarding career!

Plans, coordinates, directs, and participates in work of a smaller research project or major unit of a large research project in the field of specialization for which the incumbent is particularly qualified in terms of extensive training and/or experience.

The Levi laboratory in the Division of Burn, Trauma, Acute and Critical Care Surgery in the Department of Surgery has an opening for a Research Scientist. The Levi lab s mission is to improve the lives of people living with skin and musculoskeletal injuries and diseases through rigorous science and compassion. Current projects in the Levi laboratory are related to the molecular biology behind tissue fibrosis and the repair and regeneration process in tendon, muscle, and bone.

The laboratory integrates multiomics-based approaches with investigations of musculoskeletal development, homeostasis, repair, and regeneration. The laboratory uses transgenic animal models combined with bioinformatic approaches to understand the cell-cell interactions that occur within the stem cell niche under physiological conditions and strives to understand how these divergent signaling mechanisms may guide future therapeutic strategies to promote faithful repair of damaged tissue.

The Levi Lab is looking for a Research Scientist with an Osteosarcoma focus to join the team who is willing to commit to at least two years. The Research Scientist will support ongoing bench and animal work within the lab related to tendon injury/fibrosis, muscle injury/fibrosis or bone/tendon/muscle regeneration. Duties will include routine molecular bench work combined with the use of animal models (animal handling, injections, surgeries, sample collection) as well as downstream processing (histology, immunofluorescent stain and confocal imaging, flow cytometry, cell culture, single cell and bulk RNA sequencing) under supervision of the PI.

• Routine molecular bench work combined with the use of animal models
• Animal handling, injections, modified diet maintenance, surgeries, and sample collection
• Downstream processing
• Histology, immunofluorescent stain and confocal imaging, flow cytometry, and work with cell cultures and single-cell and bulk RNA sequencing

• Able to utilize a variety of molecular biology techniques, including but not limited to PCR, qPCR, western blotting, RNA/DNA extraction, cloning, CRISPR/Cas9 gene editing, and next generation sequencing.
• Experience with animal handling, animal breeding, genotyping, and animal surgery.
• Experience with single-cell transcriptomic analyses.
• Experience with histology pipeline from tissue harvest to embedding, sectioning, staining, and confocal microscopy.
• Experience with flow cytometry and mass spectrometry.
• Excellent written and oral communication and organizational skills.
• Able to perform data analysis and interpretation using bioinformatics tools, statistical methods, and relevant software packages.

• Animal breeding, genotyping, handling, and surgery
• Molecular biology techniques, including but not limited to PCR, qPCR, western blotting, RNA/DNA extraction, cloning, CRISPR/Cas9 gene editing, and next generation sequencing.
• Flow cytometry and mass spectrometry.
• Histology pipeline from tissue harvest to embedding, sectioning, staining, and confocal microscopy.
• Design and execute experiments to investigate molecular mechanisms underlying biological processes.
• Plan and develop standard operating protocols for experimental protocols.
• Review and analyze resulting research data.
• Revise techniques or approaches to work problems that are indicated as necessary by research data.
• May confer with industrial, governmental, or other groups concerning progress or results of research project.
• Maintain a respectful and inclusive laboratory environment.
• Maintain a clean and functional workspace.
• Analyze and interpret experimental data using relevant software and statistical methods.
• Stay current with advances in molecular biology research and contribute to the development of new…