PhD Student Infection Biology and Field Assisted Biofabrication

Start of work:
Position will remain open until role is filled, preferred start by October 2026.

Duration: 4 years

Fracture-related infection (FRI) remains one of the most challenging complications in orthopaedic trauma, frequently resulting in bone destruction, implant failure, and prolonged treatment. Recent evidence suggests that early infection-induced bone loss is primarily driven by neutrophil-mediated inflammation and proteolytic degradation, alongside classical osteoclast-driven pathways.

This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to further our knowledge on this topic by developing a novel human‑relevant 3D in vitro model that integrates:

• Spatially organized bone constructs generated using Sound‑Induced Morphogenesis
• Integration of immune cell populations including neutrophils
• Controlled introduction of Staphylococcus aureus
• Advanced molecular and imaging‑based readouts

The project will enable mechanistic insights into infection‑induced osteolysis and provide a platform for testing new therapeutic strategies.

• Develop and optimise 3D biofabricated bone model with immune cells
• Establish infection models with Staphylococcus aureus
• Introduce and study neutrophil‑driven inflammatory processes
• Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling)
• Analyse and interpret experimental data
• Contribute to scientific publications and presentations

• Master’s degree in biomedical engineering, biology, microbiology, or a related field
• Experience in cell culture and laboratory techniques (e.g. molecular biology, microscopy, microbiology)
• Experience in neutrophil handling and culture
• Experience in planning and executing research experiments
• Strong interest in infection biology, immunology, and/or biomaterials
• Excellent communication skills in English
• Ability to work independently as well as collaboratively in an interdisciplinary environment
• High motivation and enthusiasm for research

• Experience with 3D cell culture or tissue models
• Knowledge of host–pathogen interactions or infection models
• Familiarity with biofabrication, hydrogels, or biomaterials
• Exposure to advanced imaging or omics approaches

• An interesting and varied job in an exciting and innovative organization
• The opportunity to be part of a highly committed international team
• Modern infrastructure
• High degree of flexibility regarding working hours and location (depending on operational requirements)
• Generous package of social benefits, including supplementary vacation days and pension scheme contributions
• Internal skills training opportunities and support for continued education