Director, Screening and Content Analysis

Position: Director, Screening and High Content Analysis
As the Director, Screening and High Content Analysis, you will lead the development and execution of NGNRI’s high-content screening platform, driving target discovery and therapeutic development using advanced organoid and cell-based models.

This role will design and scale automated screening workflows that integrate high-content imaging, quantitative image analysis, and data science approaches, including AI-driven methods. As a scientific and technical leader, you will ensure seamless integration of screening capabilities with NGNRI’s broader research platforms and strategic priorities.

This is a key leadership position with a clear mandate: to build and manage robust, high throughput screening and analysis systems that accelerate the discovery of therapeutic targets and compounds for NF1 and related neurological disorders.

About the role Establish and lead NGNRI’s high-content imaging and screening platform

Design and implement automated screening workflows for organoid and cell-based assays

Develop and optimize imaging assays, phenotypic readouts, and quantitative analysis pipelines

Integrate AI/ML-based approaches for image analysis and pattern recognition

Ensure scalability, robustness, and reproducibility of screening pipelines

Collaborate closely with the Head of Cell Culture and Organoids to align biological models with screening requirements

Recruit, train, and manage a multidisciplinary team (biologists, imaging scientists, data analysts)
Oversee data management, storage, and analysis pipelines, ensuring accessibility and integrity

Partner with internal and external researchers to design screening campaigns for target identification and drug discovery

Continuously evaluate emerging technologies in imaging, automation, and computational analysis

Contribute to interpretation of screening results and downstream validation strategies

Ensure compliance with relevant regulatory, data governance, and ethical standards

About you High integrity and commitment to scientific excellence Innovative and technology-driven mindset Strong leadership and team development skills Collaborative and interdisciplinary approach Detail-oriented with strong organizational skills Adaptable and results-driven

Preferred Qualifications Significant experience in high-content imaging, phenotypic screening, or related fields Proven track record in designing and executing automated screening campaigns Expertise in image analysis tools and platforms (e.g., Cell Profiler, ImageJ, Python based pipelines, or equivalent)

Experience with AI/ML approaches applied to biological imaging data is highly desirable Experience working with complex biological systems such as organoids or stem cell derived models is a strong asset Demonstrated leadership experience in academic, biotech, or pharmaceutical environments Strong analytical and problem-solving skills Excellent communication and cross-functional collaboration abilities Experience managing large datasets and computational workflows Familiarity with drug discovery pipelines is advantageous PhD in bioengineering, computational biology, neuroscience, cell biology, or related discipline

What you’ll get Our team members fuel our strategy, innovation and growth, so we ensure the health and well-being of not just you, but your family, too! We go above and beyond to give you the support you need on an individual level and offer all sorts of ways to help you live your best life. We are proud to offer eligible team members perks and health benefits that will help you have peace of mind.

Simply put:
We’ve got your back. Check out our full list of Benefits and Perks.

About us The Nick Gilbert Neurofibromatosis Research Institute (NGNRI) is a nonprofit organization focused on developing…