Research Associate in Native Ambient Mass Spectrometry

Research Associate in Native Ambient Mass Spectrometry

SALARY: From £38,500 per annum (depending on skills and experience)

LOCATION: Didcot, Oxfordshire

JOB TYPE: 3 Years, Full-Time, Fixed Term Contract

The Rosalind Franklin Institute (the Franklin) is a technology institute established by the UK Government as a unique centre committed to advancing tools that are needed to transform healthcare in the future.

The Institute brings together researchers in life and physical sciences, and engineering, to develop a spectrum of tools which we will use to image, interpret and intervene in biological systems. These insights will speed up the discovery of new medicines, help find new diagnostics and contribute to a deeper understanding of human health and disease. Our Science Strategy seeks to focus the Franklin s research and unite our researchers around our Technology Innovation Challenges and Life Science Challenges.

We seek to recruit a postdoctoral research associate to undertake research in native ambient mass spectrometry imaging. The ideal candidate will have experience in at least two of the following: native mass spectrometry, top-down mass spectrometry, mass spectrometry imaging, ion source development, instrument development.

As a Research Associate at the Franklin, you will bring scientific knowledge and skills to deliver a specific research project and/or you will bring independent, creative science, or specific skills to a team delivering a project or program. Through this work, you will build scientific independence, develop new science and leadership skills and establish a growing reputation externally.

In this role, you will be responsible for developing tools for native ambient mass spectrometry, including nano-DESI and related techniques, and integration of NAMS with other structural biology techniques. You will collaborate closely with internal and external stakeholders to develop innovative solutions for improved mass spectrometry imaging of intact proteins and their assemblies in tissue and advancing integrative spatial and structural biology.

The project will be hosted in the new Rosalind Franklin Institute facilities at Harwell but will also involve working with investigators across the Franklin, collaborator laboratories and with member institutes.

Key Responsibilities

As a Research Associate you will:

• Develop new tools for native ambient mass spectrometry imaging.
• Design, model and construct new instrumentation to enable chemical imaging.
• Collaborate with biological and MS experts at the Franklin to optimise MSI conditions and methods for specific collaborations and challenges.
• Adapt to working across multi-modal instrumentation and collating multiomic and imaging data from diverse sources and scales.
• Investigate the use of cutting edge instrumentation to explore key scientific challenges such as sensitivity and spatial resolution.
• Plan and conduct experiments, analyse and interpret results and supervised delivery of outputs (e.g. research report, patent application) in a scientific or technology area of interest.
• Work within a project team, contributing to wider projects around Franklin's key Challenges.
• Lead major contributions to outputs from research including papers, patents and both internal and external presentations.
• Support and develop others including day-to-day supervision of students or visitors in areas related to own research.
• Have supervised, staged progression to first stages of scientific independence with opportunities to further develop science and skills/experience.
• Enhance your research through collaboration with other researchers and make active contributions to exchanging of ideas through your own network.
• Be able to understand, interpret, create and communicate appropriately within a research context.
• Develop search and discovery skills and techniques.
• Be supervised by a Scientist/Senior Scientist in delivery of research outputs, either in the context of a project or Challenge or as an early career development fellow.

This job description sets out the skills and experience we believe are needed to be able to do this job but, research also tells us women are much more…