Method Development Lead
Job in
Doncaster, South Yorkshire, DN1, England, UK
Listed on 2026-09-30
Listing for:
Nexus Life Sciences
Full Time
position Listed on 2026-09-30
Job specializations:
-
Healthcare
Job Description & How to Apply Below
We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.
This role combines technical expertise and team leadership.
Responsibilities- Key duties include:
- Leading method development and validation as a subject matter expert.
- Optimising analytical extraction techniques, chromatography methods, and LC columns.
- Managing and mentoring the Method Development & Validation team.
- Ensuring compliance with GLP, SOPs, and international guidelines.
- Troubleshooting analytical methods and recommending improvements.
- Overseeing cost-effective laboratory operations and consumable spend.
- Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
- Supporting regulatory submissions and resolving regulatory queries.
- Conducting investigations, implementing CAPAs, and driving continuous improvement.
- Preparing, reviewing, and ensuring adherence to GLP SOPs.
- Leading team meetings and staff development sessions.
- Degree in Biochemistry, Biomedical Science, or related field.
- 4+ years in a GxP laboratory (2+ years in management).
- Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
- Proficiency in method development, optimisation, and validation.
- Strong problem-solving and troubleshooting capabilities.
- Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
- Understanding of regulatory and GLP requirements.
- Strong communication, organisational, and leadership skills.
- Experience with Design of Experiments (DOE) for method optimisation.
- Proficiency in Minitab/statistical software.
- Experience with Empower and Mass Lynx data systems.
- GC experience and familiarity with regulatory inspections.
- Competitive salary up to £60,000.
- Leadership opportunity in a cutting-edge lab environment.
- Professional development and training opportunities.
- Supportive, collaborative work culture.
- Chance to contribute to innovative bioanalytical projects.
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