Lead Research Chemist - Medicinal Chemistry

About the Role

Our client is actively seeking a dynamic Lead Research Chemist to guide their medicinal chemistry efforts in Durban. This critical role involves leading the design, synthesis, and optimization of novel small molecules with therapeutic potential. You will be responsible for directing synthetic chemistry projects, troubleshooting complex synthetic routes, and ensuring the timely delivery of high-quality compounds for preclinical evaluation. This position offers a unique opportunity to contribute significantly to drug discovery programs within a collaborative and innovative research setting.

• Lead the design and synthesis of novel chemical entities (NCEs) targeting specific disease pathways using advanced organic synthesis techniques.
• Optimize lead compounds for improved potency, selectivity, pharmacokinetic properties, and safety profiles through iterative design-make-test-analyze cycles.
• Manage and mentor a team of research chemists, providing technical guidance and fostering a productive laboratory environment.
• Collaborate closely with biologists, pharmacologists, and computational chemists to advance drug discovery projects from hit identification to lead optimization.
• Develop and implement innovative synthetic strategies to access challenging molecular targets efficiently.
• Ensure all laboratory activities are conducted safely and in compliance with company policies and regulatory guidelines in Durban.

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field with a strong emphasis on synthetic organic chemistry.
• Minimum of 7 years of experience in drug discovery, with a substantial portion focused on medicinal chemistry within the pharmaceutical or biotech industry.
• Demonstrated expertise in modern synthetic organic chemistry, including asymmetric synthesis, heterocyclic chemistry, and purification techniques.
• Proven ability to design and execute complex synthetic routes and solve challenging chemical problems.
• Experience leading scientific projects and mentoring junior chemists.
• Excellent communication and interpersonal skills, with a strong track record of collaboration and publication.

• A highly competitive salary package, recognizing the experience and leadership offered.
• Comprehensive health benefits including medical aid, and wellness programs.
• Generous annual leave and company-paid holidays.
• Opportunities for professional development, including participation in leading chemistry conferences.
• Access to state-of-the-art synthesis labs and analytical equipment in Durban.