Experienced Nurse - Peds Transplant and Cellular Therapy​/Oncology

At Duke Health, we’re driven by a commitment to compassionate care that changes the lives of patients, their loved ones, and the greater community. No matter where your talents lie, join us and discover how we can advance health together.

About Duke University Hospital

Pursue your passion for caring with Duke University Hospital in Durham, North Carolina, which is consistently ranked among the best in the United States. The largest of Duke Health’s four hospitals with 1062 patient beds, it features comprehensive diagnostic and therapeutic facilities, including a regional emergency/trauma center, an endo-surgery center, and more.

• Duke University Health System is designated as a Magnet organization
• Nurses from each hospital are consistently recognized each year as North Carolina’s Great 100 Nurses.
• Duke University Health System was awarded the American Board of Nursing Specialties Award for Nursing Certification Advocacy for being strong advocates of specialty nursing certification.
• Duke University Health System has 6000 + registered nurses
• Quality of Life:
  Living in the Triangle!
• Relocation Assistance (based on eligibility)

Registered Nurse – Pediatric Transplant & Cellular Therapy/Oncology
Duke University Hospital
Full Time | Day/Night Rotating |

Duke University Health System seeks to hire an experienced Registered Nurse with a passion for high-acuity, relationship-centered pediatric care to join our Pediatric Transplant & Cellular Therapy/Oncology Unit. This team plays a vital role in Duke Children’s mission of Advancing Health Together.

This 17-bed blended pediatric specialty unit cares for a unique and complex patient population, including:

• Stem cell transplant recipients
• Cellular therapy patients (including CAR-T)
• Pediatric oncology patients with high-risk hematologic malignancies and brain tumors
• Children with sickle cell disease, metabolic disorders, and genetic conditions

The unit supports longer-term continuity-based care with an average length of stay of ~30 days, allowing nurses to develop deep and meaningful connections with patients and families.

• Transplant & cellular therapy patients: ICU-level ("ICU light")
• Oncology patients: step-down acuity

• RN-to-patient ratio: 1:1 to 1:3 depending on acuity
• Free-standing charge nurse 24/7 (no patient assignment)
• Health Unit Coordinator 24/7
• Nursing Assistants/NCAs on unit daily (7a–7p)
• Multidisciplinary rounds with active RN collaboration

As a Clinical Nurse II, you will deliver comprehensive, evidence-based care in alignment with the medical and nursing plans of care.

Responsibilities include:

• Perform thorough pediatric assessments and ongoing monitoring of high-acuity transplant, cellular therapy, and oncology patients.
• Plan, provide, and document individualized nursing care using the nursing process.
• Administer chemotherapy, immunotherapy, and supportive regimens.
• Provide central line management (Broviac, Port-A-Cath, PICC).
• Administer and monitor blood products.
• Identify and respond to early signs of clinical deterioration.
• Educate patients and families on treatment, expectations, and home care.
• Delegate and supervise care delivered by licensed and unlicensed personnel.
• Serve as charge nurse or team leader as needed.
• Act as a preceptor and support the growth of new staff and learners.
• Contribute to clinical and operational performance improvement initiatives.

• Chemotherapy certification
• Cellular therapy and transplant competencies
• Management of:
  • Engraftment syndrome
  • Graft-versus-host disease (GVHD)
  • Cytokine Release Syndrome (CRS)
  • Neurotoxicity (ICANS)
• Advanced pediatric critical thinking and interdisciplinary communication

• A fast-paced, highly collaborative environment
• Relationship-based nursing with long-term patients and families
• Involvement in daily rounds and care planning
• Opportunities to grow in one of Duke’s highest-acuity pediatric care settings

• Paid training: 4–6 weeks of orientation based on experience
• Clinical Ladder advancement opportunities
• Tuition assistance
• Specialty certification…