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Job Description & How to Apply Below
The Role
Reporting to Jan (Head of Protein Sciences), the Scientist (Protein Sciences) drives the development, optimization, and characterization of purification workflows and analytical assays that inform and advance our larval recombinant‑protein platform. This vital role combines rigorous process development with scientific discovery to understand platform behaviour and improve product quality. As a trusted owner of key initiatives, the role is responsible for independently executing experiments and translating results into novel methodologies that expand the platform’s capabilities.
This position moves beyond following protocols to proactively troubleshoot and provide the high‑quality data essential to scaling our impact.
This Role Will Own
Executing complex end‑to‑end purification workflows to isolate high‑quality target proteins from our unique biological matrices.
Building and refining a modular library of extraction and purification protocols that work across diverse protein classes.
Conducting deep‑dive investigations into purification hurdles, such as protein aggregation, low recovery, or persistent impurities, to enhance the fundamental robustness of the platform.
Analyzing multidimensional datasets to generate “protein profiles” that provide critical feedback for upstream genetic design and downstream application development.
Performing analytical assays, including SDS‑PAGE and Western Blotting, to verify protein identity, purity, and structural integrity.
Maintaining meticulous, real‑time documentation within Benchling (ELN) to ensure platform insights are preserved, searchable, and actionable for the broader team.
This Role Will Assist By
Collaborating across teams including CDMO, Genetics, and Manufacturing to connect molecular architecture with final protein performance.
Acting as a trusted, supportive teammate in the lab, identifying and resolving technical bottlenecks before they impact project timelines.
About You
You are a disciplined researcher who thrives in the (sometimes) messy reality of a startup. You are a proactive collaborator who values transparency and can work independently without losing sight of the team's shared goals. You approach technical challenges with a sense of ownership and are eager to contribute to a mission that is transforming the future of biotech.
Must-haves
MSc with ≥2 years’ or BSc with ≥4 years’ relevant experience in recombinant protein expression, purification and characterization.
Proven hands‑on experience with chromatographic purification (affinity, ion‑exchange, HIC, SEC) and filtration workflows at bench scale.
Experience running analytical assays for product quality (SDS‑PAGE, Western, activity assays) and ability to interpret data to guide process decisions.
Demonstrated ability to design and execute complex experiments and prioritize competing projects, and deliver results on time.
Strong documentation practices and experience with ELN and protocol repositories (Benchling or equivalent).
Excellent communication and cross‑functional collaboration skills; comfortable working directly with upstream and engineering teams to connect molecular design with purification outcomes.
Proactive, solution‑oriented, with strong attention to detail and a bias for rapid iteration and learning.
Bonus points
Familiarity with SPR, HPLC, mass spectrometry or other analytical techniques is an asset.
Experience with AKTA systems or automated liquid handling.
Familiarity with insect‑based expression or other non‑traditional platforms.
Within 1 Month, You Will
Complete full safety and platform training for our larval recombinant‑protein system. Understand the unique nuances of extracting proteins from complex insect matrices.
Successfully execute a standard end‑to‑end purification workflow (extraction to final elution) and perform fundamental analytical assays (SDS‑PAGE, Western Blot) to confirm platform baseline metrics.
Establish a daily rhythm in Benchling, ensuring all experimental designs, deviations, and results are documented with the level of detail required for cross‑functional audit.
Integrate with the R&D team to understand the current "pain points" in the…
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