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Job Description & How to Apply Below
About the role
Reporting to Jan (Head of Protein Sciences), the Scientist (Protein Sciences) drives the development, optimization, and characterization of purification workflows and analytical assays that inform and advance our larval recombinant‑protein platform. This vital role combines rigorous process development with scientific discovery to understand platform behaviour and improve product quality. The role is responsible for independently executing experiments, translating results into novel methodologies, and proactively troubleshooting to provide high‑quality data essential to scaling our impact.
Responsibilities
Executing complex end‑to‑end purification workflows to isolate high‑quality target proteins from our unique biological matrices.
Building and refining a modular library of extraction and purification protocols that work across diverse protein classes.
Conducting deep‑div investigations into purification hurdles to enhance platform robustness.
Analyzing multidimensional datasets to generate protein profiles that provide critical feedback upstream.
Performing analytical assays, including SDS‑PAGE and Western Blotting, to verify protein identity, purity, and structural integrity.
Maintaining meticulous real‑time documentation within Benchling (ELN) to preserve platform insights.
Additional duties
Collaborating with CDMO, Genetics and Manufacturing to connect molecular architecture with final protein performance.
Acting as a trusted teammate in the lab, identifying and resolving technical bottlenecks before they impact project timelines.
About you
You are a disciplined researcher who thrives in the sometimes messy reality of a startup. You are a proactive collaborator, value transparency, and can work independently without losing sight of the team’s shared goals. You approach technical challenges with ownership and are eager to contribute to our mission of transforming biotech.
Requirements
MSc with ≥2 years’ or BSc with ≥4 years’ relevant experience in recombinant protein expression, purification and characterization.
Proven hands‑on experience with chromatographic purification (affinity, ion‑exchange, HIC, SEC) and filtration workflows at bench scale.
Experience running analytical assays for product quality (SDS‑PAGE, Western, activity assays) and ability to interpret data to guide process decisions.
Demonstrated ability to design and execute complex experiments, prioritize competing projects, and deliver results on time.
Strong documentation practices and experience with ELN and protocol repositories (Benchling or equivalent).
Excellent communication and cross‑functional collaboration skills; comfortable working directly with upstream and engineering teams.
Proactive, solution‑oriented, with strong attention to detail and a bias for rapid iteration and learning.
Bonus points
Familiarity with SPR, HPLC, mass spectrometry or other analytical techniques.
Experience with AKTA systems or automated liquid handling.
Familiarity with insect‑based expression or other non‑traditional platforms.
Career development roadmap
Time‑based expectations for the first year.
Within 1 month
Complete full safety and platform training for our larval recombinant‑protein system.
Successfully execute a standard end‑to‑end purification workflow and perform fundamental analytical assays to confirm platform baseline metrics.
Establish a daily rhythm in Benchling, ensuring all experimental designs, deviations, and results are documented with required detail.
Integrate with the R&D team to understand current pain points in the workflows.
Within 3 months
Identify specific bottlenecks in current purification workflows beyond following protocols.
Begin correlating purification outcomes with upstream genetic variables to provide actionable feedback to molecular teams.
Manage 1-2 research sub‑projects independently, meeting timelines without daily supervision.
Within 6 months
Lead focused investigations into purification hurdles, propose and test process adjustments to improve robustness.
Share experimental findings in cross‑functional meetings for informed decision‑making on host‑engineering strategies.
Use and refine the modular protein toolbox…
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