Post Doctoral Scientist; Biologics Development and Manufacturing

Position: Post Doctoral Scientist (Biologics Development and Manufacturing)
* Design experiments and perform hands-on buffer/media preparation and cell culture operations in shake flasks, ambr
15, ambr
250, bench-scale bioreactors, and novel cell culture platforms
* Lead aspects of optimizing chemically defined cell culture media to improve productivity and modulate product quality for fed-batch and perfusion processes
* Apply statistical and computational tools (e.g., DoE, multivariate analysis) to interpret experimental data and guide media formulation strategies
* Elucidate mechanistic understanding of key factors and associated metabolic pathways relating to cell culture medium and process development using advanced bio-analytical techniques such as bioassays, proteomics, and metabolomics
* Participate and work cross-functionally within and outside of biologics technical development to achieve common goals
* Prepare technical reports, protocols, presentations, and manuscripts for internal and external dissemination
* Occasional weekend work may be required to support cell culture operations
* Maintain accurate and detailed laboratory records in compliance with institutional and regulatory standards
* Adhere to department budget and all training, compliance and safety requirements. Support general laboratory upkeep.
* Ph.D. in a relevant scientific discipline (Biology, Biochemistry, Bioengineering, Chemical Engineering, Biomolecular Engineering) with 0-2 years of relevant experience OR expected PhD graduation within 6 months from date of application
* Motivated self-starter with organizational and problem-solving skills. Excellent verbal communication, oral presentation, and scientific writing skills
* Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design
* Passion for inclusion: knowing the business value of diverse teams, modelling inclusion, and embedding the value of diversity in the way they work
* Hands-on laboratory operations experience in CHO cell culture including shake flask, high-throughput bioreactor (e.g., ambr
15, ambr
250), bench scale bioreactor in parallel operation
* Experience with serum-free, chemically defined media optimization
* Solid understanding of CHO cell metabolism, bioprocessing, and media formulation principles
* Experience with tools for metabolic pathway analyses and bio-analytical techniques such as proteomics, metabolomics, and bioassays for gene expression analysis to guide media optimization
* Experience with kinetic modeling and computational tools (e.g., Python, R, MATLAB)
* Experience in statistics, design-of-experiments, and data analysis (e.g. JMP, Spotfire)
* Proven track record of external presentations and/or publications in peer-reviewed journals

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or (d) otherwise protected by law.
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