Principal Scientist, Protein Therapeutics

Ph.D. in biochemistry, structural biology or a related field with 6+ years (postdoctoral training preferred)
** OR
* * M.S. with 8+ years (16+ years preferred)
** OR
* * B.S. with 10+ years (18+ years preferred) of additional experience in an academic or industrial setting and a record of accomplishments in the form of high impact publications or patents
* Extensive experience advancing protein therapeutics from discovery to development and stays abreast with emerging protein engineering platforms and technologies
* Expertise in structure-based protein engineering and design of multispecifics, immunocytokines, Fc engineering, and fusion proteins
* Skilled practitioner in antibody engineering, including humanization, sequence liability remediation, and/or biophysical property improvement
* Project leadership experience in Research across multiple therapeutic areas, with deep understanding of hit-to-lead selection through preclinical development of therapeutic candidates
* Presentation and high impact publication record with demonstrable protein engineering expertise
* Proficient in various molecular biology and/or library building techniques (e.g. PCR fragment assembly, vector design, site-directed mutagenesis, Gibson assembly, and/or Golden gate cloning), as well as hands-on experience (preferred) with mammalian cell culture, protein expression, purification, and characterization; in vitro and in vivo antibody discovery approaches is a plus
* Experience with computational design tools preferred (e.g. Rosetta, MOE, or Discovery Studio)
* Team player with strong collaboration, communication, organizational skills, and excellent problem-solving skills
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