PhD Student; d​/f​/m translational Myeloma Research

Responsibilities

• Translational PhD project focused on identifying biomarkers that enable early prevention and prediction of the progression from myeloma precursor stages to active disease
• Development and evaluation of targeted therapeutic strategies for patients with hard-to-treat myeloma
• Perform a genome-wide cancer screen in CCND1- and MMSET-deregulated plasma cell tumors in a mouse model
• Characterize resulting tumors in depth using a broad spectrum of bulk and single-cell analyses, with close collaboration and synergies with a parallel single-cell project from our group at the BIMSB
• Validate the most promising candidate genes involved in myelomagenesis using preclinical models
• Conduct subsequent mechanistic studies and translate findings into the human disease context, with the possibility of independently performing bioinformatic analyses
• Application of a wide range of methods and technologies: mouse experiments, single-cell analyses, RNA/DNA sequencing, protein biochemistry, flow cytometry, CRISPR-Cas9 gene editing, bioinformatics/data science
• Work with diverse model systems: genetically modified preclinical models (including mice), cell lines, primary patient material, and patient datasets
• You are engaged in scientific work, and in accordance with §110 (4) sentence 3 of the BerlHG (Berlin Higher Education Act), an appropriate amount of time is granted to you for your own scientific qualification

• Master’s degree (or equivalent) in biology, biochemistry, molecular medicine, computational biology, pharmacy, bioengineering, or a related field
• High motivation, strong commitment, and excellent communication skills
• Solid knowledge of molecular and cell biology
• Excellent proficiency in English, both written and spoken
• Desirable: prior experience with preclinical models (e.g., FELASA certificate) and/or bioinformatic analyses