Senior Bacterial Core Technician

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The Alaka`ina Foundation Family of Companies (FOCs) has a potential need for a Senior Bacterial Core Technician to support our government customer located in Fort Detrick, Frederick, MD
.

DESCRIPTION OF RESPONSIBILITIES:

• Responsible for BSL-3 laboratory operations and training in animal manipulations. Technicians shall perform approximately 5 animal studies in both the DTRA funded projects as well as contracted work.
• Perform in vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria.
• Participate in mouse, rat, rabbit, or other small animal studies, which include preparation of antibiotics for administration, administering drugs and vaccines, orally and by intraperitoneal, intramuscular, subcutaneous, and intravenous bolus injections.
• Participate in weekly lab meetings and assist in development and design with current and future in vitro and in vivo work.
• Participate in mouse, rat, rabbit, or other small animal BSL-2 pharmacokinetics and toxicology studies; to include preparation of antibiotics for administration; administering drugs and vaccines, followed by blood and tissue collection for pharmacokinetic or pharmacodynamic analyses.
• Support the in vivo pharmacology research program and contribute to the multidisciplinary research team to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads.
• Assist with data analyses and drafting reports for internal or external customers.
• Work with mass spectrometry, chromatography, HPLC MS/MS, specifically Sciex platforms coupled with Shimadzu HPLCs other and biophysical techniques to support in-process testing and characterization of biopharmaceutical products and impurities.
• Perform bioanalytical data acquisition, data analysis, and reporting of results using Applied Biosystems Analyst, Excel, and the Mass Spec Quantitation Software Multi Quant.
• Complete approximately 25 media/reagent preparations per year.
• Assist with approximately 5 animal challenges per year and 10 bacterial challenge preparations.
• Perform approximately 400 animal injections per year; 400 animal observations per year.
• Support divisional in vivo projects by completing approximately 500 bacterial burdens in animal tissue per year.
• Perform approximately 500 small animal necropsies per year.
• Process approximately 300 animal gavage and approximately 125 animal blood collections per year.
• Place approximately 50 GFEBs orders per year for supplies and equipment.
• Maintain laboratories in BSL-2 and BSL-3.
• Perform or assist with BSAT Inventory Management weekly (to include applicable BSAT working stock material).
• Conduct or assist with Equipment Inventory Management twice a year in BSL-2 and BSL-3.
• Perform or assist with monthly Laboratory Management to include safety functions and chemical inventory.
• Review relevant literature monthly.
• Maintain a GLP training folder and be compliant with all GLP regulations when applicable.
• Directly contribute to the design, rationale, and be point-of-contact for 10 small animal studies to include drafting of a study plan and oversight of personnel scheduling.
• Contribute to study progress reports and scientific manuscripts to include statistical analysis, data compilation, figure preparation, and methods summary.
• Assist in establishing up to 28 new active material transfer agreements and cooperative research and development agreements with up to 8 pharmaceutical companies and/or universities.
• Other duties as assigned by Supervisor.

REQUIRED DEGREE/

EDUCATION/CERTIFICATION:

Bachelor's degree in Biology, Microbiology or similar science and 5 years of relevant laboratory experience.

REQUIRED

SKILLS AND EXPERIENCE:

• Must have a minimum of two (2) to three (3) years performing BSL-3 laboratory operations and training in animal manipulations and conducting animal studies.
• Must have a minimum of two (2) to three (3) years performing in-vitro Minimum Inhibition Concentration (MIC) testing of potential therapeutic compounds against Tier 1 bacteria.
• Must be willing to work with diversity sets of Bacillus…