Postdoctoral Associate in cryogenic electron microscopy; CryoEM

Position: Postdoctoral Associate in cryogenic electron microscopy (CryoEM)
Postdoctoral Associate in cryogenic electron microscopy (CryoEM)

Job No: 535647
Work Type: Post Doc Associate
Location: Palm Beach
Categories: Biology/Life Science, Physical/Mathematical Sciences
Department:  - SR-CHEM-IZARD LAB

Job Description

Classification

Title:

Postdoctoral Associate

Job Description:

Postdoctoral Associate positions are immediately available in Professor Tina Izard's cell adhesion laboratory.

The laboratory collaborates with several other laboratories on campus including exciting collaborative and currently active projects with Professors Kirill Martenmyanov ((Use the "Apply for this Job" box below)..abl
4732), Kendall Nettles (), Susana Valente (), and Luiz Carvalho ().

Thus, there are several exciting opportunities for a variety of very interesting projects beyond structure-function studies of cytoskeletal proteins that control signaling downstream of adherens junctions and focal adhesions with implications in cancer and heart diseases and more recently structure-function studies of novel Mycobacterium tuberculosis targets in collaboration with Professor Luiz Carvalho ().

The laboratory is recognized as a world leader and provides outstanding training in protein biochemistry and structural, molecular, and cellular biology, in a highly dynamic and team-oriented research program.

Successful candidates will work in a cutting-edge research environment with new state-of-the-art facilities. The laboratory has outstanding facilities for cell biology, molecular biology, protein expression, purification, and biochemistry, and cryogenic electron microscopy, and protein crystallography. The laboratory has access to a large cast of outstanding Cores that facilitate basic research and drug development. The unique infrastructure includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for the discovery of novel biomolecules.

Professor Tina Izard is a board member of the South East Regional Collaborative Access Team (SER-CAT) that constructed two beam lines at the Advanced Photon Source (APS) at Argonne National Laboratory. The insertion device and bending magnet beam lines are available for all the synchrotron-related data collection needs for the post-doctoral associates.

Professor Tina Izard recently installed the first 300 kV cryo Atomic Resolution Microscope (cryoARM
300) in the Americas () and has plenty of microscope time dedicated to the post-doctoral associate. This state-of-the-art transmission electron microscope is a 300 kV high resolution microscope capable of carrying out cryogenic-electron microscopy studies by providing atomic resolution for structural studies involving single particle analyses. The transmission electron microscope is equipped with new and improved Gatan K3 direct electron detector camera that has better DQE, larger field of view (24 Megapixels - 5,760 x 4,092) and faster (3.75 times that of K2 camera).

The direct detection devices are exquisitely sensitive, produce high signal to noise images, and are ideal for high-resolution studies.

Professor Izard designed and installed a High Flux X-ray diffraction system, specifically a Rigaku Micro Max-007 HF, a second-generation microfocus rotating anode generator together with a mar
345 Image Plate detector. An Osmic Vari Max optics system and the Proteros Free Mounting System can be used to control the humidity and to optimize diffraction characteristics, including resolution, mosaicity, and anisotropy, as well as reduced X-ray background.

Expected Salary:

NRSA Minimum Salary.

Minimum Requirements:

Applicants with a recently awarded Ph.D. degree in a relevant scientific discipline.

Preferred Qualifications:

• Experience in cryogenic electron microscopy (cryo
  
  EM).
• Any structural biologist is highly encouraged to apply.

Special Instructions to Applicants:

In order to be considered, please upload a cover letter and resume.

For any inquiries, you may contact Dr. T. Izard, at t.izard

The final candidate will be…