Senior Scientist, Computational Protein Engineering

POSITION SUMMARY

This position is responsible for planning and developing an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company. The incumbent will be responsible for developing workflows for the de novo design of antibodies and proteins. This position assists in identifying and implementing departmental initiatives and strategies. This position may/will supervise the work of others directly and/or across interdisciplinary teams.

• Independently designs and develops an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company
• Develops computational pipelines for protein structure determination using structural and/or sequence-based methods and/or artificial intelligence methods (e.g. Rosetta, Alpha Fold)
• Develops computational pipelines for protein docking and antibody epitope mapping
• Independently combines data from different sources and analyzes these or incorporates these into multidimensional optimization of protein interactions
• Leads a technical team to implement computational pipelines in protein design, engineering, or prediction
• Critically evaluates experimental data and incorporates this knowledge into design
• Provides input to the management team to identify, develop, and execute departmental initiatives and strategies.
• Leads technical team(s) to accomplish project goals and manages/coordinates work of other team members.
• Presents findings/analyses and any associated issues/solutions to peer groups and managers; make recommendations for project advancement.
• Leads cross-functional initiatives with other business units on projects/products or associated deliverables.
• Establishes and monitors direct report performance and development goals, assigns accountabilities, sets objectives, establishes priorities, and provides continuous coaching and recognition on performance.
• Stays current with technological developments in area of expertise, expands knowledge through independent learning.
• Maintains organized, detailed and clear project records for self and direct reports.
• Understands, follows and enforces laboratory safety precautions to ensure compliance with company safety policies.
• Specific duties may vary depending upon departmental requirements.

• PhD in structural bioinformatics, molecular biology, bioengineering, biophysics, computational biology, or related field with 2 years of relevant experience
• Expertise with protein and antibody modeling, including antigen-antibody interactions
• Publications in the form of high-profile papers/patents within protein prediction or de novo protein design, including antibody or enzyme engineering.
• Experience with artificial intelligence and/or machine learning methods is desirable.

• Proven record of remaining current, learning new techniques/research in areas of computational biochemistry
• Superior scientific fundamentals and analytical background.
• Ability to work independently and in teams, and to collaborate with external parties
• Excellent communication skills and the ability to work in a highly dynamic and collaborative environment
• Expert problem solving skills and demonstrated ability to organize and move project tasks forward in an orderly and structured fashion.
• Strong analytical skills with the demonstrated ability to gather and evaluate complex data and information and develop a recommendation and plan of action.
• Excellent organizational, planning, and time management skills required, with the ability to manage multiple and often changing priorities and issues of varying complexity while meeting time-sensitive deadlines and deliverables.
• Strong leadership skills with demonstrated knowledge and understanding of staff management practices and processes. Ability to establish accountabilities and expectations and manage performance to achieve results.
• Demonstrated propensity to be creative, collaborative, proactive, and self-motivated in the execution and completion of assigned tasks.
• Exceptional communication (written and verbal) skills regardless of the format (e.g., documents, public speaking situations, presentations, etc.).
• Project-level understanding and attention to detail with demonstrated commitment to excellence and performance.
• Proven proficiency with Microsoft Office (i.e., Word, Excel, PowerPoint, Outlook).

• While performing the duties of this job, the individual is frequently required to sit and stand for long periods. The individual is occasionally required to walk; use hands and fingers to operate, handle, or feel objects, tools, or controls; reach with hands and arms.
• Up to 10 % of the day may be spent at a laboratory bench.
• There are aspects of the position's duties that require a person in this role to work at heights above four (4) feet on occasion and move/lift up to 25 pounds.

• Laboratory environment…