Senior Associate Scientist - Assay Development

Assay Development Group

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. Regeneron’s Assay Development Group (ADG), located in Tarrytown, NY, is seeking a Sr Associate Scientist to join our team. In this role, you will develop/optimize and execute mass spectrometry-based methods to quantify and investigate biologics, siRNAs, and novel antibody conjugates; generate high-quality data; and communicate findings that advance programs across the pipeline.

This position offers the opportunity to work cross-functionally in a fast-paced, science-driven environment, applying technical expertise, creativity, and sound scientific judgment to solve complex challenges and help deliver meaningful therapies to patients worldwide.

Tarrytown, NY

• Optimize, troubleshoot, and execute quantitative mass spectrometry assays for biomarkers, therapeutic proteins, peptides, siRNAs, antibody conjugates, small molecules, and linker-payloads.

• Perform hands-on laboratory work using HPLC/UHPLC, mass spectrometry, King Fisher-based purification or extraction, and related quantitation/characterization techniques.

• Analyze and interpret complex datasets; maintain accurate electronic laboratory notebook records; and present findings clearly to technical, departmental, leadership, and cross-functional audiences.

• Manage multiple assays and projects concurrently and evaluate emerging technologies and assay formats.

• Maintain GLP-compliant laboratory practices and documentation for assay validations in accordance with FDA regulations and company SOPs.

• Collaborate within Bioanalytical Sciences, across Regeneron, and with CROs to troubleshoot challenges, align priorities, and support program execution.

• A Bachelor’s or Master’s degree in Biophysics, Biochemistry, Chemistry, Engineering, or a related field, with at least 3 to 6 years of relevant industry experience appropriate to level.

• Ability to independently design experiments, analyze and interpret data, draw sound conclusions, and communicate findings to technical and cross-functional audiences.

• Hands on experience in operating and troubleshooting HPLC/UHPLC and mass spectrometry instrumentation (QQQ, Q-TOF and Orbitrap).

• Strong initiative, scientific curiosity, organization, and ability to prioritize multiple projects with minimal supervision in a collaborative environment.

• Excellent oral and written communication skills and a commitment to timely, compliant laboratory documentation.

• Preferred:
  Experience developing and executing quantitative mass spectrometry assays to support PK, PD, biomarker bioanalysis for large molecule therapeutic modalities.

• Preferred:
  Experience with King Fisher systems, high-throughput extraction, and other related automated sample preparation platforms. Experience in samples preparation for immunoaffinity capture, SPE and other fit-for-purpose bioanalytical approaches in different biological matrices.

• Preferred:
  Experience in developing novel bioanalytical assay platforms or introducing new assay formats and emerging technologies.

• Preferred:
  Understanding of protein/antibody structure-function relationships and PK/PD principles.

• Preferred:
  Biopharmaceutical industry experience, including collaboration with cross-functional teams and external partners such as CROs.

• Preferred:
  Prior experience in bioanalytical (regulated) assay execution and able to work collaboratively with a team mindset.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race,…