Scientist, Cardiac Vascular - In Vivo

Build our future together:
At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team, serving as a key contributor to the design and execution of longitudinal in‑vivo rodent studies supporting our cardiovascular disease programs. In this role, you will perform advanced surgical models of cardiac disease, conduct precision dosing and physiological monitoring, and generate high-quality functional and molecular data to support target validation and therapeutic development.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

• Location:
  
  Tarrytown, NY

• Work model/flexibility:
  Onsite

• Perform surgical models of cardiac and vascular disease in mice and rats, including transverse aortic constriction (TAC), myocardial infarction (MI), and renal/kidney models (RKM)

• Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation with precision and consistency across longitudinal study timelines

• Implant and manage telemetry devices for continuous blood pressure and ECG monitoring in conscious, freely moving rodents

• Conduct invasive hemodynamic assessments using PV-loop methodology to quantify cardiac function

• Perform ex‑vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion

• Manage end‑to‑end in‑vivo study logistics, including animal health monitoring, surgical scheduling, and post‑operative care

• Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software

• Generate high‑quality figures, reports, and data summaries for internal presentations, regulatory packages, and peer‑reviewed publications

• Maintain rigorous records of surgical procedures, animal welfare documentation, and study protocols in compliance with institutional and regulatory standards

• Collaborate closely with study directors, therapeutic area scientists, and cross‑functional teams to align surgical and analytical approaches with program goals

• Proactively flag capacity constraints, scheduling conflicts, or technical challenges to stakeholders

• BS with 10+ years, MS with 6+ years with relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar)

• Demonstrated hands‑on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM)

• Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation for blood pressure and ECG monitoring

• Experience with invasive hemodynamic measurement techniques, including PV-loop analysis

• Hands‑on experience with Langendorff perfusion and cardiac tissue dissociation

• Proficiency with data analysis software such as PRISM and PONEMAH

• Strong understanding of rodent anatomy, physiology, and survival surgery best practices

• Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously

• Strong attention to detail and commitment to scientific rigor and animal welfare standards

• Excellent oral and written communication skills

• Preferred: experience with additional cardiovascular functional assessment techniques or prior work in a GLP/regulated research environment

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or…