Senior Scientist; Molecule Protein

Senior Scientist (Protein Sciences – Small Molecule)

£41,700 – £48,000 plus benefits

Department:
Therapeutic Innovation, R&I

Reports to:

Principal Scientist

Location:

CRUK Scotland Institute, Glasgow Lab (Low flex: minimum 3 days per week on site)

Contract type:
Permanent, full time 35 hours per week

Closing date:
Sunday 19th July, 23:55pm

We have an exciting opportunity for a Senior Scientist in Protein Sciences to join Cancer Research Horizons in our Glasgow lab. You will lead the expression, purification and quality control of protein antigens and related molecules, focusing on small‑molecule drug discovery. Working primarily across bacterial and insect systems, you will deliver high‑quality, well‑characterised proteins using biochemical and biophysical methods, and collaborate closely with multidisciplinary drug‑discovery teams.

• Expression and purification of recombinant proteins using bacterial and insect systems to support screening and crystallography programmes.
• Ensure all production is sufficiently characterised and QC’d using appropriate biochemical and biophysical methods.
• Interpret, analyse and clearly summarise data for presentation to varied audiences.
• Work collaboratively within multidisciplinary research teams.
• Communicate effectively, demonstrating openness and respect for others’ perspectives.
• Prioritise workload according to project objectives and take responsibility for timely delivery.
• Drive scientific and technical innovation, including through internal and external collaborations, while staying current with developments in the field.
• Maintain accurate and up‑to‑date electronic laboratory notebook records.
• Take responsibility for assigned laboratory equipment and associated duties.
• Uphold safe, compliant and effective working practices.

• PhD or equivalent in Molecular Sciences, Protein Sciences, Chemistry or significant experience within a drug‑discovery environment.
• Significant experience in providing protein production and molecular biology expertise to enable drug‑discovery projects.
• Ability to work in a fast‑paced, quickly changing environment, showing agility and flexibility to meet deadlines and goals with a can‑do attitude.
• Use of current molecular biology techniques (PCR, cloning) to construct expression vectors and isolate genes.
• Purification of tagged and native proteins via manual, AKTA and automated purification platforms using a range of chromatographic techniques.
• Protein analytical techniques – e.g. protein quantitation assays, SDS‑PAGE analysis, HPLC, Western blotting and protein modifications such as biotinylation.
• Track record of delivering results across a diverse project portfolio by leading and driving strategic and scientific initiatives.

We value ambition, courage, determination, rigour, professionalism, a positive impact on people, and inclusivity and collaboration.

We actively encourage applications from people of all backgrounds and cultures, particularly from ethnic minority backgrounds who are currently under‑represented. If you need support with health, safety or accessibility, please contact us.

We provide a generous benefits package, a broad range of career and personal development opportunities, high‑quality tools and support for your wellbeing.