Scientist​/Senior Scientist​/Principal Scientist-Biomarker

Title:

Scientist / Senior Scientist / Principal Scientist – Biomarker Services

Location:

Hayward, CA

Reports To:

Manager/Supervisor Biomarker Company Frontage  Laboratories Inc. is an award winning, publicly listed, full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada, and China, growing significant YoY growth. Our core competencies include pre-clinical, drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Biomarker Services Frontage's Biomarker Services group provides comprehensive biomarker assay development, validation, and sample analysis support for pharmaceutical, biotechnology, and academic clients across a broad range of therapeutic areas, including oncology, neuroscience, immunology, inflammation, metabolic diseases, and rare diseases.

Our scientists have employed state-of-the-art technologies including NULISA™, SIMOA®, MSD®, Luminex®, Ella™, ELISA, LC-MS/MS, and other emerging ultra-sensitive detection platforms to deliver high-quality biomarker data that enable critical drug development decisions.

Position Summary:

The Scientist/Senior Scientist/Principal Scientist will lead and support the development, qualification, validation, transfer, and implementation of biomarker assays for preclinical and clinical studies. The successful candidate will serve as a scientific leader responsible for project execution, client interactions, regulatory compliance, and scientific innovation.

This position requires expertise in biomarker assay technologies and experience supporting regulated and non-regulated studies in a CRO, pharmaceutical, or biotechnology environment. The individual will work closely with clients, project management, quality assurance, and laboratory personnel to ensure the successful delivery of high-quality biomarker data within established timelines.

Roles and Responsibilities:

Scientific Leadership Design and lead biomarker assay development, optimization, qualification, validation, and sample analysis projects.

Act as scientific lead for biomarker studies supporting drug discovery, translational research, and clinical development.

Provide technical oversight and mentorship to research associates, scientists, and laboratory staff.

Evaluate emerging technologies and implement innovative assay solutions to meet client needs.

Identify and resolve technical and scientific challenges associated with biomarker measurements.

Assay Development & Validation Develop and validate biomarker assays for proteins, cytokines, chemokines, neurodegenerative markers, oncology biomarkers, immune biomarkers, and other translational endpoints.

Design and execute fit-for-purpose, qualified, and fully validated biomarker methods according to applicable regulatory and industry guidance.

Lead assay transfer activities from clients or partner laboratories.

Establish assay performance characteristics.

Platform Expertise Develop, troubleshoot, and validate single-plex and multiplex immunoassays using technologies including: NULISA™, SIMOA®, MSD®, Ella™, Luminex®, LC-MS/MS; and other emerging biomarker platforms as appropriate.

Project & Client Management Serve as primary scientific contact for assigned clients.

Lead client meetings and technical discussions.

Provide scientific updates, timelines, risk assessments, and project status reports.

Collaborate with business development teams during proposal preparation and study planning.

Support audits, inspections, and client visits.

Documentation & Regulatory Compliance Author, review, and approve: study protocols, validation plans, analytical…